Drug level in Sprague-Dawley rat plasma assessed as compound formation treated with [14C]brivanib alaninate at 100 mg/kg, po administered as single dose via gavage measured after 1 hr by HPLC analysis
Drug level in Sprague-Dawley rat plasma assessed as compound formation treated with [14C]brivanib alaninate at 100 mg/kg, po administered as single dose via gavage measured after 2 hrs by HPLC analysis
Drug level in Sprague-Dawley rat plasma assessed as compound formation treated with [14C]brivanib alaninate at 100 mg/kg, po administered as single dose via gavage measured after 6 hrs by HPLC analysis
Drug level in cynomolgus monkey plasma assessed as compound formation treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage measured after 6 hrs by HPLC analysis
Drug level in cynomolgus monkey plasma assessed as compound formation treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage measured after 12 hrs by HPLC analysis
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 1 hr by HPLC analysis
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 2 hrs by HPLC analysis
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 4 hrs by HPLC analysis
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 8 hrs by HPLC analysis
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 12 hrs by HPLC analysis
Drug level in cynomolgus monkey plasma assessed as compound formation treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage measured after 1 hr by mass spectrometry
Drug level in cynomolgus monkey plasma assessed as compound formation treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage measured after 2 hrs by mass spectrometry
Drug level in cynomolgus monkey plasma assessed as compound formation treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage measured after 4 hrs by mass spectrometry