| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3536562 | A | Drug metabolism in dog liver microsomes assessed as ER-879123 formation at 10 uM after 60 mins in presence of NADH by LC-MS/MS method | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
| 2. | ALA3536563 | A | Drug metabolism in human liver microsomes assessed as ER-879123 formation at 10 uM after 60 mins in presence of NADH by LC-MS/MS method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 3. | ALA3536566 | A | Drug metabolism in dog liver microsomes assessed as ER-879123 formation at 10 uM after 60 mins in presence of NADH and carboxylesterase inhibitor BNPP by LC-MS/MS method | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
| 4. | ALA3536567 | A | Drug metabolism in human liver microsomes assessed as ER-879123 formation at 10 uM after 60 mins in presence of NADH and carboxylesterase inhibitor BNPP by LC-MS/MS method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 5. | ALA3536568 | A | Drug metabolism in dog liver microsomes assessed as ER-879123 formation at 10 uM after 60 mins in presence of NADH and FMO1 and FMO3 substrate/inhibitor methimazole by LC-MS/MS method | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
| 6. | ALA3536569 | A | Drug metabolism in human liver microsomes assessed as ER-879123 formation at 10 uM after 60 mins in presence of NADH and FMO1 and FMO3 substrate/inhibitor methimazole by LC-MS/MS method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 7. | ALA3536570 | A | Drug metabolism in 50 degC treated dog liver microsomes assessed as ER-879123 formation at 10 uM after 60 mins in absence of NAD+ by LC-MS/MS method | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
| 8. | ALA3536571 | A | Drug metabolism in 50 degC treated human liver microsomes assessed as ER-879123 formation at 10 uM after 60 mins in absence of NAD+ by LC-MS/MS method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA3536572 | A | Drug metabolism assessed as human recombinant FMO5-mediated ER-879123 formation at 10 uM after 60 mins by LC-MS/MS method in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA3536573 | A | Drug metabolism assessed as human recombinant FMO5-mediated ER-879123 formation in presence NADH at 10 uM after 60 mins by LC-MS/MS method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA3531401 | A | Drug metabolism assessed as human recombinant FMO1-mediated ER-879123 formation at 10 uM after 60 mins by LC-MS/MS method in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA3531402 | A | Drug metabolism assessed as human recombinant FMO1-mediated ER-879123 formation in presence NADH at 10 uM after 60 mins by LC-MS/MS method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA3531403 | A | Drug metabolism assessed as human recombinant FMO3-mediated ER-879123 formation at 10 uM after 60 mins by LC-MS/MS method in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA3531404 | A | Drug metabolism assessed as human recombinant FMO3-mediated ER-879123 formation in presence NADH at 10 uM after 60 mins by LC-MS/MS method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA3887040 | B | PARP Enzyme Assay: The PARP enzyme assay is set up on ice in a volume of 100 microliters consisting of 100 mM Tris-HCl (pH 8.0), 1 mM MgCl2, 28 mM KCl, 28 mM NaCl, 0.1 mg/ml of DNase I activated herring sperm DNA (Sigma, Mo.), 3.0 micromolar [3H]nicotinamide adenine dinucleotide (470 mci/mmole), 7 micrograms/ml PARP enzyme, and various concentrations of the compounds to be tested. The reaction is initiated by incubating the mixture at 25° C. After 15 minutes of incubation, the reaction is terminated by adding 500 microliters of ice cold 20% (w/v) trichloroacetic acid. The precipitate formed is transferred onto a glass fiber filter (Packard Unifilter-GF/B) and washed three times with ethanol. After the filter is dried, the radioactivity is determined by scintillation counting. | 17 | single protein format | BindingDB Database |
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