# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3528708 | A | Transactivation of human PXR transfected in human HepG2 cells assessed as CYP2B6 expression at 1 to 30 uM by luciferase reporter gene assay | Homo sapiens | 3 | ALA3526135 | cell-based format | Scientific Literature | |
2. | ALA3528709 | A | Transactivation of rat PXR at 0.1 to 30 uM after 24 to 48 hrs by cell-based luciferase reporter gene assay | Rattus norvegicus | 3 | ALA3526135 | cell-based format | Scientific Literature | |
3. | ALA3528710 | A | Transactivation of human AhR at 0.1 to 30 uM after 24 to 48 hrs by cell-based luciferase reporter gene assay | Homo sapiens | 3 | ALA3526135 | cell-based format | Scientific Literature | |
4. | ALA3528711 | A | Transactivation of human CAR1 transfected in human HepG2 cells assessed as CYP2B6 expression at 1 to 30 uM after 24 hrs by luciferase reporter gene assay | Homo sapiens | 3 | ALA3526135 | cell-based format | Scientific Literature | |
5. | ALA3528712 | A | Transactivation of mouse CAR1 transfected in human HepG2 cells assessed as CYP2B6 expression at 1 to 30 uM after 24 hrs by luciferase reporter gene assay | Mus musculus | 3 | ALA3526135 | cell-based format | Scientific Literature | |
6. | ALA3528714 | A | Transactivation of human CAR1 Ala retention mutant transfected in human HepG2 cells assessed as CYP2B6 expression at 1 to 30 uM after 24 hrs by luciferase reporter gene assay | Homo sapiens | 3 | ALA3526135 | cell-based format | Scientific Literature | |
7. | ALA4323334 | B | Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake at 0.05 uM incubated for 2 mins by LC-MS/MS analysis relative to control empty vector transfected cells | Homo sapiens | 21 | ALA4321821 | cell-based format | Scientific Literature | |
8. | ALA4323335 | B | Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake at 0.1 uM incubated for 2 mins by LC-MS/MS analysis relative to control empty vector transfected cells | Homo sapiens | 21 | ALA4321821 | cell-based format | Scientific Literature | |
9. | ALA4323336 | B | Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake at 0.5 uM incubated for 2 mins by LC-MS/MS analysis relative to control empty vector transfected cells | Homo sapiens | 21 | ALA4321821 | cell-based format | Scientific Literature | |
10. | ALA4323337 | B | Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake at 0.05 to 0.5 uM incubated for 2 mins in presence of 2 mM MPP+ by LC-MS/MS analysis relative to control empty vector transfected cells | Homo sapiens | 9 | ALA4321821 | cell-based format | Scientific Literature | |
11. | ALA4323339 | B | Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake by measuring Vmax incubated for 2 mins by LC-MS/MS analysis based Michaelis-Menten plot analysis relative to control empty vector transfected cells | Homo sapiens | 4 | ALA4321821 | cell-based format | Scientific Literature | |
12. | ALA4323340 | B | Substrate activity at human OCT1 expressed in HEK293 cells assessed as increase in compound uptake by measuring Km incubated for 2 mins by LC-MS/MS analysis based Michaelis-Menten plot analysis relative to control empty vector transfected cells | Homo sapiens | 5 | ALA4321821 | cell-based format | Scientific Literature | |
13. | ALA4323353 | B | Substrate activity at human OCT3 expressed in HEK293 cells assessed as increase in compound uptake up to 200 uM incubated for 2 mins by LC-MS/MS analysis based Michaelis-Menten plot analysis relative to control empty vector transfected cells | Homo sapiens | 1 | ALA4321821 | cell-based format | Scientific Literature | |
14. | ALA4323354 | B | Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysis | Homo sapiens | 23 | ALA4321821 | cell-based format | Scientific Literature | |
15. | ALA4323355 | A | Passive membrane permeability by LC-MS/MS analysis based PAMPA | 23 | ALA4321821 | assay format | Scientific Literature |