Drug uptake in human plasma treated with [14C]brivanib alaninate assessed as AUC (0 to 12 hrs) of total radio activity at 800 mg, po administered as single oral dose by HPLC analysis
Drug level in Sprague-Dawley rat plasma assessed as compound formation treated with [14C]brivanib alaninate at 100 mg/kg, po administered as single dose via gavage measured after 1 hr by HPLC analysis
Drug level in Sprague-Dawley rat plasma assessed as compound formation treated with [14C]brivanib alaninate at 100 mg/kg, po administered as single dose via gavage measured after 2 hrs by HPLC analysis
Drug level in Sprague-Dawley rat plasma assessed as compound formation treated with [14C]brivanib alaninate at 100 mg/kg, po administered as single dose via gavage measured after 6 hrs by HPLC analysis
Drug level in cynomolgus monkey plasma assessed as compound formation treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage measured after 1 hr by HPLC analysis
Drug level in cynomolgus monkey plasma assessed as compound formation treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage measured after 2 hrs by HPLC analysis
Drug level in cynomolgus monkey plasma assessed as compound formation treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage measured after 4 hrs by HPLC analysis
Drug level in cynomolgus monkey plasma assessed as compound formation treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage measured after 6 hrs by HPLC analysis
Drug level in cynomolgus monkey plasma assessed as compound formation treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage measured after 12 hrs by HPLC analysis
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 1 hr by HPLC analysis
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 2 hrs by HPLC analysis
Drug uptake in cynomolgus monkey plasma treated with [14C]brivanib alaninate assessed as AUC (0 to 4 hrs) of total radio activity at 10 mg/kg, po administered as single oral dose by HPLC analysis
Drug uptake in Sprague-Dawley rat plasma treated with [14C]brivanib alaninate assessed as AUC (0 to 6 hrs) of total radio activity at 100 mg/kg, po administered as single oral dose by HPLC analysis
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 4 hrs by HPLC analysis
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 8 hrs by HPLC analysis
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 12 hrs by HPLC analysis