| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3537989 | A | Drug metabolism in human liver microsomes at 10 uM after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 2. | ALA3537990 | A | Drug metabolism in human liver S9 fraction at 10 uM after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 3. | ALA3538010 | A | Drug metabolism in human liver microsomes assessed as (3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3-methyldecahydronaphtho[2,3-c]furan-1(3H)-one formation at 10 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA3538011 | A | Drug metabolism in human liver S9 fraction assessed as (3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3-methyldecahydronaphtho[2,3-c]furan-1(3H)-one formation at 10 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 5. | ALA3538012 | A | Activity of human recombinant CYP1A1 assessed as enzyme-mediated drug metabolism at 10 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA3538013 | A | Activity of human recombinant CYP1A2 assessed as enzyme-mediated drug metabolism at 10 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA3538014 | A | Activity of human recombinant CYP2B6 assessed as enzyme-mediated drug metabolism at 10 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA3538015 | A | Activity of human recombinant CYP2C9 assessed as enzyme-mediated drug metabolism at 10 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA3538016 | A | Activity of human recombinant CYP2C19 assessed as enzyme-mediated drug metabolism at 10 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA3538017 | A | Activity of human recombinant CYP2D6 assessed as enzyme-mediated drug metabolism at 10 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA3538018 | A | Activity of human recombinant CYP3A4 assessed as enzyme-mediated drug metabolism at 10 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA3538019 | A | Activity of human recombinant CYP3A5 assessed as enzyme-mediated drug metabolism at 10 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA3541165 | A | Drug metabolism in human liver microsomes assessed as (3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3-methyldecahydronaphtho[2,3-c]furan-1(3H)-one formation after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA3541166 | A | Intrinsic clearance in human liver microsomes assessed as (3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3-methyldecahydronaphtho[2,3-c]furan-1(3H)-one formation by measuring Vmax/Km per nmol of enzyme after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA3533873 | A | Drug metabolism in human liver microsomes assessed as (3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3-methyldecahydronaphtho[2,3-c]furan-1(3H)-one formation per nmol of enzyme at 25 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 16. | ALA3534176 | A | Activity of human recombinant CYP3A4 assessed as enzyme-mediated (3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3-methyldecahydronaphtho[2,3-c]furan-1(3H)-one formation per nmol of enzyme at 25 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA3531396 | A | Activity of human recombinant CYP4F12 assessed as enzyme-mediated 2-hydroxyethyl (1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-ylcarbamate formation at 25 uM after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA3529560 | A | Activity of human recombinant CYP3A5 assessed as enzyme-mediated (3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3-methyldecahydronaphtho[2,3-c]furan-1(3H)-one formation at 25 uM after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA3529562 | A | Activity of human recombinant CYP1A2 assessed as enzyme-mediated (3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3-methyldecahydronaphtho[2,3-c]furan-1(3H)-one formation at 25 uM after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA3529564 | A | Activity of human recombinant CYP4F3A assessed as enzyme-mediated (3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3-methyldecahydronaphtho[2,3-c]furan-1(3H)-one formation at 25 uM after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature |
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