# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3579877 | Binding | Activity of TOP2A in human K562 cells assessed as poisoning activity at 100 uM after 1 hr by TARDIS assay | Homo sapiens | 5 | ALA3576785 | cell-based format | Scientific Literature | |
2. | ALA3579878 | Binding | Activity of TOP2B in human K562 cells assessed as poisoning activity at 100 uM after 1 hr by TARDIS assay | Homo sapiens | 5 | ALA3576785 | cell-based format | Scientific Literature | |
3. | ALA3580054 | Binding | Activity of TOP2 in human K562 cells assessed as poisoning activity by measuring phosphorylation of gamma-H2AX at Ser139 at 100 uM after 1 hr by DAPI staining-based epifluorescence microscopic analysis | Homo sapiens | 6 | ALA3576785 | cell-based format | Scientific Literature | |
4. | ALA3580055 | Functional | Cytotoxicity against wild type human NALM6 cells assessed as growth inhibition after 5 days by XTT assay | Homo sapiens | 6 | ALA3576785 | cell-based format | Scientific Literature | |
5. | ALA3580056 | Functional | Cytotoxicity against human NALM6 cells expressing 50% TOP2A assessed as growth inhibition after 5 days by XTT assay | Homo sapiens | 6 | ALA3576785 | cell-based format | Scientific Literature | |
6. | ALA3580057 | Functional | Cytotoxicity against TOP2B double knockout human NALM6 cells assessed as growth inhibition after 5 days by XTT assay | Homo sapiens | 6 | ALA3576785 | cell-based format | Scientific Literature | |
7. | ALA3580058 | Functional | Selectivity ratio of IC50 for human NALM6 cells expressing 50% TOP2A to IC50 for wild type human NALM6 cells | Homo sapiens | 6 | ALA3576785 | cell-based format | Scientific Literature | |
8. | ALA3580059 | Functional | Selectivity ratio of IC50 for TOP2B double knockout human NALM6 cells to IC50 for wild type human NALM6 cells | Homo sapiens | 6 | ALA3576785 | cell-based format | Scientific Literature |