| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3580176 | B | Inhibition of Kv2.1 channel in human INS1 cells assessed as inhibition of outward K+ current by electrophysiology/patch clamp technique | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA3862623 | F | Inhibition of RANKL-induced mouse BMDM cell differentiation assessed as reduction in TRAP-positive multi-nucleated osteoclast cells preincubated for 5 mins followed by RANKL/M-CSF addition measured after 4 days by light microscopic analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA3862624 | F | Inhibition of RANKL-induced mouse BMDM cell differentiation assessed as reduction in TRAP activity at 0.1 to 30 uM using p-nitrophenyl phosphate as substrate preincubated for 5 mins followed by RANKL/M-CSF addition measured after 4 days | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA3862625 | F | Inhibition of RANKL-induced mouse BMDM cell differentiation assessed as TRAP-positive MNCs at 0.1 to 30 uM preincubated for 5 mins followed by RANKL/M-CSF addition measured after 4 days by TRAP-staining based assay | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA3862626 | T | Cytotoxicity against mouse BMDM cells assessed as reduction in cell viability at 30 uM after 3 days in presence of M-CSF by CCK-8 assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA3862627 | B | Inhibition of RANKL-induced p38 phosphorylation in mouse BMDM cells assessed as ratio of phosphorylated p38 to p38 at 10 uM preincubated for 5 mins followed RANKL/M-CSF addition for 5 mins by Western blot analysis (Rvb = 24.7 No_unit) | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA3862628 | B | Inhibition of RANKL-induced ERK1 phosphorylation in mouse BMDM cells assessed as ratio of phosphorylated ERK1 to ERK1 at 10 uM preincubated for 5 mins followed RANKL/M-CSF addition for 5 mins by Western blot analysis (Rvb = 2.9 No_unit) | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA3862629 | B | Inhibition of RANKL-induced ERK2 phosphorylation in mouse BMDM cells assessed as ratio of phosphorylated ERK2 to ERK2 at 10 uM preincubated for 5 mins followed RANKL/M-CSF addition for 5 mins by Western blot analysis (Rvb = 2.6 No_unit) | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA3862630 | B | Inhibition of RANKL-induced JNK2 phosphorylation in mouse BMDM cells assessed as ratio of phosphorylated JNK2 to JNK2 at 10 uM preincubated for 5 mins followed RANKL/M-CSF addition for 5 mins by Western blot analysis (Rvb = 5.2 No_unit) | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA3862631 | B | Inhibition of RANKL-induced JNK1 phosphorylation in mouse BMDM cells assessed as ratio of phosphorylated JNK1 to JNK1 at 10 uM preincubated for 5 mins followed RANKL/M-CSF addition for 5 mins by Western blot analysis (Rvb = 3.7 No_unit) | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA3862632 | B | Inhibition of RANKL-induced AKT phosphorylation in mouse BMDM cells assessed as ratio of phosphorylated AKT to AKT at 10 uM preincubated for 5 mins followed RANKL/M-CSF addition for 5 mins by Western blot analysis (Rvb = 2.1 No_unit) | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA3862633 | F | Inhibition of RANKL-induced c-Fos expression in mouse BMDM cells assessed as ratio of c-Fos to actin at 10 uM preincubated with cells followed RANKL/M-CSF addition measured after 1 day by Western blot analysis (Rvb = 6.4 No_unit) | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA3862634 | F | Inhibition of RANKL-induced NFATc1 expression in mouse BMDM cells assessed as ratio of NFATc1 to actin at 10 uM preincubated with cells followed RANKL/M-CSF addition measured after 1day by Western blot analysis (Rvb = 281 No_unit) | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA3862635 | F | Inhibition of RANKL-induced mouse BMDM cell differentiation assessed as TRAP-positive MNCs at 0.1 to 10 uM preincubated for 5 mins followed by RANKL/M-CSF addition measured after 4 days by TRAP-staining based assay | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA3862636 | T | Cytotoxicity against mouse BMDM cells assessed as reduction in cell viability up to 10 uM after 3 days in presence of M-CSF by CCK-8 assay | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA3862637 | F | Inhibition of RANKL-induced NFATc1 mRNA expression in mouse BMDM cells at 10 uM preincubated with cells followed by RANKL addition measured after 2 days by real-time PCR analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA3862638 | F | Inhibition of RANKL-induced TRAP mRNA expression in mouse BMDM cells at 10 uM preincubated with cells followed by RANKL addition measured after 2 days by real-time PCR analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA3862639 | F | Inhibition of RANKL-induced OSCAR mRNA expression in mouse BMDM cells at 10 uM preincubated with cells followed by RANKL addition measured after 2 days by real-time PCR analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA3862640 | F | Inhibition of RANKL-induced c-Src mRNA expression in mouse BMDM cells at 10 uM preincubated with cells followed by RANKL addition measured after 2 days by real-time PCR analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 20. | ALA3862641 | F | Inhibition of RANKL-induced DC-STAMP mRNA expression in mouse BMDM cells at 10 uM preincubated with cells followed by RANKL addition measured after 2 days by real-time PCR analysis | Mus musculus | 3 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!