# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3579738 | Binding | Inhibition of ASIC1a in Wistar rat hippocampal neurons assessed as ASIC1a-like currents level at 10 uM by patch clamp assay | Rattus norvegicus | 1 | ALA3576804 | assay format | Scientific Literature | |
2. | ALA3579739 | Binding | Inhibition of ASIC3 in Wistar rat hippocampal neurons assessed as fast ASIC3-like currents level at 10 uM by patch clamp assay | Rattus norvegicus | 1 | ALA3576804 | assay format | Scientific Literature | |
3. | ALA3579740 | Binding | Inhibition of ASIC2 in Wistar rat hippocampal neurons assessed as slow ASIC2-like currents level at 10 uM by patch clamp assay | Rattus norvegicus | 1 | ALA3576804 | assay format | Scientific Literature | |
4. | ALA3579741 | Binding | Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 6.7 by standard whole cell patch clamp assay | Homo sapiens | 1 | ALA3576804 | cell-based format | Scientific Literature | |
5. | ALA3579742 | Binding | Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 5.0 by standard whole cell patch clamp assay | Homo sapiens | 1 | ALA3576804 | cell-based format | Scientific Literature | |
6. | ALA3579743 | Binding | Reversible inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 6.7 measured after drug wash out by standard whole cell patch clamp assay | Homo sapiens | 1 | ALA3576804 | cell-based format | Scientific Literature | |
7. | ALA3579913 | Binding | Reversible inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 5.0 measured after drug wash out by standard whole cell patch clamp assay | Homo sapiens | 1 | ALA3576804 | cell-based format | Scientific Literature | |
8. | ALA3579916 | Binding | Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at 100 nM by standard whole cell patch clamp assay | Homo sapiens | 1 | ALA3576804 | cell-based format | Scientific Literature | |
9. | ALA3579917 | Binding | Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -20 mV gated ionic current at 100 nM by standard whole cell patch clamp assay | Homo sapiens | 1 | ALA3576804 | cell-based format | Scientific Literature | |
10. | ALA3579919 | Binding | Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at 100 nM in presence of cellular membrane depolarization by standard whole cell patch clamp assay | Homo sapiens | 1 | ALA3576804 | cell-based format | Scientific Literature | |
11. | ALA3579920 | Binding | Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as EC50 for steady state activation at 10 nM by standard whole cell patch clamp assay (Rvb = 6.57 +/- 0.01 pH) | Homo sapiens | 1 | ALA3576804 | cell-based format | Scientific Literature | |
12. | ALA3579921 | Binding | Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as EC50 for steady state activation at 100 nM by standard whole cell patch clamp assay (Rvb = 6.57 +/- 0.01 pH) | Homo sapiens | 1 | ALA3576804 | cell-based format | Scientific Literature | |
13. | ALA3579922 | Binding | Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as EC50 for steady state activation at 1 uM by standard whole cell patch clamp assay (Rvb = 6.57 +/- 0.01 pH) | Homo sapiens | 1 | ALA3576804 | cell-based format | Scientific Literature | |
14. | ALA3579923 | Binding | Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as maximal evoked response for steady-state activation at 10 nM by standard whole cell patch clamp assay relative to untreated control | Homo sapiens | 1 | ALA3576804 | cell-based format | Scientific Literature | |
15. | ALA3579924 | Binding | Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as maximal evoked response for steady-state activation at 100 nM by standard whole cell patch clamp assay relative to untreated control | Homo sapiens | 1 | ALA3576804 | cell-based format | Scientific Literature | |
16. | ALA3579925 | Binding | Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as maximal evoked response for steady-state activation at 1 uM by standard whole cell patch clamp assay relative to untreated control | Homo sapiens | 1 | ALA3576804 | cell-based format | Scientific Literature | |
17. | ALA3579926 | Binding | Inhibition of ASIC1a in Wistar rat pyramidal hippocampal neurons assessed as ASIC1a-like currents level at 100 nM by patch clamp assay | Rattus norvegicus | 1 | ALA3576804 | assay format | Scientific Literature | |
18. | ALA3579927 | Binding | Inhibition of ASIC1a in Wistar rat pyramidal hippocampal neurons assessed as reduction in main ionic currents at 1 uM by patch clamp assay | Rattus norvegicus | 1 | ALA3576804 | assay format | Scientific Literature | |
19. | ALA3579928 | Functional | Effect on slope of field excitatory postsynaptic potential in Wistar rat hippocampal CA3-CA1 region at 100 nM by patch clamp method | Rattus norvegicus | 1 | ALA3576804 | tissue-based format | Scientific Literature | |
20. | ALA3578388 | Functional | Effect on amplitude of field excitatory postsynaptic potential in Wistar rat hippocampal CA3-CA1 region at 100 nM by patch clamp method | Rattus norvegicus | 1 | ALA3576804 | tissue-based format | Scientific Literature |