| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3578531 | A | Effect on alpha-actin level in human Jurkat cells at 6 to 20 uM after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA3578532 | A | Effect on alpha-actin level in human HH cells at 6 to 20 uM after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA3578533 | B | Inhibition of HDAC in human HH cells assessed as increase in alpha-tubulin acetylation at 6 to 20 uM after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA3578534 | B | Inhibition of HDAC in human Jurkat cells assessed as increase in alpha-tubulin acetylation at 6 to 20 uM after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA3578536 | A | Drug degradation in human plasma assessed as other product formation after 2 hrs by HPLC analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 6. | ALA3578541 | P | Retention time of the compound in HEPES buffer at pH 7.4 by LC-MS analysis in presence of GSH | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 7. | ALA3578543 | P | Aqueous stability in 50 mM HEPES buffer at pH 7.4 by HPLC chromatogram | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA3578544 | B | Inhibition of human recombinant HDAC1 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 9. | ALA3578545 | B | Inhibition of human recombinant HDAC2 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 10. | ALA3578546 | B | Inhibition of human recombinant HDAC3 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 11. | ALA3578547 | B | Inhibition of human recombinant HDAC6 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 12. | ALA3578548 | B | Inhibition of human recombinant HDAC8 using MAZ1675 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 13. | ALA3578549 | A | Stability of the compound assessed as bovine serum albumin-mediated drug degradation measured as compound remaining after 2 hrs by biochemical assay | Bos taurus | 1 | single protein format | Scientific Literature | ||
| 14. | ALA3578550 | A | Stability of the compound assessed as trypsin (unknown origin)-mediated drug degradation measured as compound remaining after 2 hrs by biochemical assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA3578551 | B | Binding affinity to human wild type HDAC8 assessed as retention time for protein fragment after 60 mins of treatment in presence of trypsin (Rvb = 84.5 mins) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA3578552 | B | Binding affinity to human wild type HDAC8 assessed as loss of activity measured with in 0.5 hrs by Fluor-de-Lys activity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA3578553 | B | Reversible-time dependent inhibition of human wild type HDAC8 by Fluor-de-Lys activity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA3578554 | B | Binding affinity to human wild type HDAC8 assessed as loss of activity at 2 to 8 uM by Fluor-de-Lys activity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA3578555 | B | Binding affinity to human Zn2+-HDAC8 assessed as loss of activity by Fluor-de-Lys activity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA3578556 | B | Reversible-time dependent inhibition of human wild type HDAC8 assessed as rate constant by Fluor-de-Lys activity assay | Homo sapiens | 1 | single protein format | Scientific Literature |
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