| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3578410 | B | Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells after 45 mins | Homo sapiens | 13 | ALA3576859 | cell-based format | Scientific Literature | |
| 2. | ALA3578411 | A | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as compound remaining at 1 uM after 15 mins | Rattus norvegicus | 7 | ALA3576859 | assay format | Scientific Literature | |
| 3. | ALA3578412 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 15 mins | Homo sapiens | 7 | ALA3576859 | assay format | Scientific Literature | |
| 4. | ALA3578413 | B | Displacement of [3H]-astemizole from human ERG expressed in HEK293 cells after 60 mins by scintillation counting analysis | Homo sapiens | 7 | ALA3576859 | cell-based format | Scientific Literature | |
| 5. | ALA3578414 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM after 60 mins by LC/MS/MS analysis | Homo sapiens | 7 | ALA3576859 | cell-based format | Scientific Literature | |
| 6. | ALA3578415 | A | Apparent permeability across basolateral to apical side in human Caco2 cells at 10 uM after 40 mins by LC/MS/MS analysis | Homo sapiens | 7 | ALA3576859 | cell-based format | Scientific Literature | |
| 7. | ALA3578416 | A | Clearance in Sprague-Dawley rat | Rattus norvegicus | 7 | ALA3576859 | organism-based format | Scientific Literature | |
| 8. | ALA3578417 | A | Volume of distribution at steady state in Sprague-Dawley rat | Rattus norvegicus | 7 | ALA3576859 | organism-based format | Scientific Literature | |
| 9. | ALA3578418 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 7 | ALA3576859 | organism-based format | Scientific Literature | |
| 10. | ALA3578419 | A | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg | Rattus norvegicus | 7 | ALA3576859 | organism-based format | Scientific Literature | |
| 11. | ALA3578420 | P | Dissociation constant, pKa of the compound | 3 | ALA3576859 | small-molecule physicochemical format | Scientific Literature | ||
| 12. | ALA3578421 | P | Lipophilicity, log P of the compound | 3 | ALA3576859 | small-molecule physicochemical format | Scientific Literature | ||
| 13. | ALA3578422 | P | Distribution coefficient, log D of the compound at pH 7.4 | 3 | ALA3576859 | small-molecule physicochemical format | Scientific Literature | ||
| 14. | ALA3578423 | A | Drug uptake in Sprague-Dawley rat brain at 3 mg/kg, po measured at 1 hr | Rattus norvegicus | 6 | ALA3576859 | organism-based format | Scientific Literature | |
| 15. | ALA3578424 | F | Ex vivo histamine H3 receptor occupancy in Sprague-Dawley rat striatum at 3 mg/kg, po measured at 1 hr by autoradiographic analysis | Rattus norvegicus | 6 | ALA3576859 | organism-based format | Scientific Literature | |
| 16. | ALA3578593 | B | Binding affinity to human adenosine A1 receptor at 1 uM | Homo sapiens | 4 | ALA3576859 | single protein format | Scientific Literature | |
| 17. | ALA3578594 | B | Binding affinity to human adenosine A2A receptor at 1 uM | Homo sapiens | 4 | ALA3576859 | single protein format | Scientific Literature | |
| 18. | ALA3578595 | B | Binding affinity to human adenosine A3 receptor at 1 uM | Homo sapiens | 4 | ALA3576859 | single protein format | Scientific Literature | |
| 19. | ALA3578596 | B | Binding affinity to rat adrenergic alpha1 receptor at 1 uM | Rattus norvegicus | 4 | ALA3576859 | assay format | Scientific Literature | |
| 20. | ALA3578597 | B | Binding affinity to rat adrenergic alpha 2 receptor at 1 uM | Rattus norvegicus | 4 | ALA3576859 | assay format | Scientific Literature |
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