# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3580016 | B | Inhibition of human recombinant full-length Fyn using Src substrate peptide after 15 mins incubation by MicroBeta liquid scintillation counting analysis | Homo sapiens | 31 | ALA3576773 | single protein format | Scientific Literature | |
2. | ALA3580017 | F | Antiproliferative activity against human K562 cells assessed as vitality after 72 hrs by automatic cell counting analysis | Homo sapiens | 11 | ALA3576773 | cell-based format | Scientific Literature | |
3. | ALA3580050 | B | Inhibition of Fyn in human differentiated SH-SY5Y cells assessed as inhibition of Abeta42 mediated phosphorylation of Tau protein at Tyr18 after 1.5 hrs by Western blot analysis | Homo sapiens | 2 | ALA3576773 | cell-based format | Scientific Literature | |
4. | ALA3580051 | B | Inhibition of Fyn in human differentiated SH-SY5Y cells assessed as inhibition of Abeta42 mediated phosphorylation of Tau protein at Tyr18 after 6 hrs by Western blot analysis | Homo sapiens | 2 | ALA3576773 | cell-based format | Scientific Literature | |
5. | ALA3580052 | F | Induction of cell cycle arrest in human K562 cells assessed as accumulation at G1 phase after 48 hrs by propidium iodide staining-based cytofluorimetry | Homo sapiens | 2 | ALA3576773 | cell-based format | Scientific Literature | |
6. | ALA3580053 | F | Induction of apoptosis in human K562 cells assessed as accumulation of hypodiploid cells at 0.01 uM | Homo sapiens | 1 | ALA3576773 | cell-based format | Scientific Literature | |
7. | ALA3580212 | F | Induction of apoptosis in Ph+ CML patient CD34+ early hematopoietic progenitor cells assessed as increase in apoptotic level at 2 uM after 48 hrs by Annexin V-FITC/Propidium iodide staining based FACSCalibur flow cytometry | Homo sapiens | 2 | ALA3576773 | assay format | Scientific Literature | |
8. | ALA3580213 | A | Cytotoxicity against human fibroblast at 2 uM after 48 hrs | Homo sapiens | 2 | ALA3576773 | cell-based format | Scientific Literature | |
9. | ALA3580214 | F | Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition after 20 to 70 hrs by Real-time RTCA iCELLgence system | Homo sapiens | 2 | ALA3576773 | cell-based format | Scientific Literature | |
10. | ALA3580215 | F | Anticancer activity against human U87 cells assessed as cell growth inhibition after 20 to 70 hrs by Real-time RTCA iCELLgence system | Homo sapiens | 2 | ALA3576773 | cell-based format | Scientific Literature | |
11. | ALA3580216 | P | Permeability of the compound by PAMPA-LC-UV analysis | 5 | ALA3576773 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA3580392 | P | Permeability of the compound by BBB-PAMPA-LC-UV analysis | 5 | ALA3576773 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA3580393 | P | Solubility of the compound in water after 24 to 36 hrs by LC-MS-MS analysis | 5 | ALA3576773 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA3580394 | A | Metabolic stability in human liver microsomes measured after 1 hr in presence of NADPH generating system | Homo sapiens | 5 | ALA3576773 | assay format | Scientific Literature | |
15. | ALA3580395 | A | Drug metabolism in human liver microsomes assessed as 2-(4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-phenylethanone formation at measured after 1 hr by LC-UV-MS analysis | Homo sapiens | 5 | ALA3576773 | assay format | Scientific Literature | |
16. | ALA3580396 | A | Drug metabolism in human liver microsomes assessed as 2-(4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-phenylethanol formation at measured after 1 hr by LC-UV-MS analysis | Homo sapiens | 5 | ALA3576773 | assay format | Scientific Literature | |
17. | ALA3580397 | A | Drug metabolism in human liver microsomes assessed as metabolite M3 formation at measured after 1 hr by LC-UV-MS analysis | Homo sapiens | 1 | ALA3576773 | assay format | Scientific Literature | |
18. | ALA4362320 | F | Antiproliferative activity against human DOHH2 cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 14 | ALA4359870 | cell-based format | Scientific Literature | |
19. | ALA4362321 | F | Antiproliferative activity against human Farage cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 14 | ALA4359870 | cell-based format | Scientific Literature | |
20. | ALA4362322 | F | Antiproliferative activity against human SUDHL8 cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 14 | ALA4359870 | cell-based format | Scientific Literature |