| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3578615 | B | Displacement of [125I]-MCH (4 to 19) from human MCH1 receptor expressed in CHO cell membranes at 0.1 uM after 1 hr by liquid scintillation counting analysis relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA3578616 | F | Antagonist activity at human MCH1 receptor expressed in CHO cell membranes assessed as inhibition of MCH (4 to 19)-stimulated calcium mobilization at 0.1 uM measured every 2 secs by fluorometric analysis relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA3578617 | F | Anoretic effect in po dosed diet-induced obese F344/Jcl rat assessed as food intake suppression rate measured for 2 days relative to control | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 4. | ALA3578618 | B | Inhibition of human ERG expressed in CHO cells at 10 uM after 5 mins by IonWorks assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA3795817 | T | Mutagenicity in Salmonella typhimurium TA1537 assessed as increase in number of revertant colony up to 5000 ug/plate by Ames test in absence of S9 fraction | Salmonella enterica subsp. enterica serovar Typhimurium | 4 | organism-based format | Scientific Literature | ||
| 6. | ALA3795818 | B | Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr liquid scintillation counting | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 7. | ALA3795821 | B | Displacement of [125I]-MCH(4 to 19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting | Rattus norvegicus | 12 | cell-based format | Scientific Literature | ||
| 8. | ALA3795823 | F | Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ mobilization measured every 2 secs by fluorometric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA3795824 | F | Anorectic effect in DIO-F344/Jcl rat at 3 mg/kg, po administered for 2 days started 2 hrs prior to onset of dark period measured during compound dosing | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA3795825 | F | Antiobesity activity in DIO-F344/Jcl rat assessed as reduction in body weight at 3 mg/kg, po dosed for 2 weeks and measured every 2 or 3 days relative to vehicle control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA3795826 | F | Anorectic effect in DIO-F344/Jcl rat at 10 mg/kg, po administered for 2 days started 2 hrs prior to onset of dark period measured during compound dosing | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA3795827 | F | Antiobesity activity in DIO-F344/Jcl rat assessed as reduction in body weight at 5 mg/kg, po dosed for 2 weeks and measured every 2 or 3 days relative to vehicle control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA3795828 | F | Antiobesity activity in DIO-F344/Jcl rat assessed as reduction in body weight at 10 mg/kg, po dosed for 2 weeks and measured every 2 or 3 days relative to vehicle control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA3795829 | A | Fraction unbound in DIO-F344/Jcl rat plasma at 10 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3795830 | A | Ratio of unbound plasma concentration in DIO-F344/Jcl rat at 10 mg/kg, po to IC50 for rat MCHR1 expressed in CHO cell membranes | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3795831 | F | Anorectic effect in wild type mouse assessed as reduction in food intake | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3795832 | T | Toxicity in MCHR deficient mouse assessed as effect on food intake | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3795833 | A | Trough plasma concentration in DIO-F344/Jcl rat at 10 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3795834 | A | Unbound plasma concentration in DIO-F344/Jcl rat at 10 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3795835 | A | Ratio of drug level in brain to plasma in po dosed DIO-F344/Jcl rat | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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