# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3584220 | B | Inhibition of human recombinant B-Raf V600E mutant by FRET-based Z'-lyte assay | Homo sapiens | 20 | ALA3580536 | single protein format | Scientific Literature | |
2. | ALA3584623 | F | Antiproliferative activity against human COLO205 cells expressing B-Raf V600E mutant incubated for 68 hrs by MTT assay | Homo sapiens | 20 | ALA3580536 | cell-based format | Scientific Literature | |
3. | ALA3584624 | F | Antiproliferative activity against human HCT116 cells expressing wild type B-Raf incubated for 68 hrs by MTT assay | Homo sapiens | 20 | ALA3580536 | cell-based format | Scientific Literature | |
4. | ALA3584625 | F | Antiproliferative activity against human LoVo cells expressing wild type B-Raf incubated for 68 hrs by MTT assay | Homo sapiens | 3 | ALA3580536 | cell-based format | Scientific Literature | |
5. | ALA3584626 | F | Antiproliferative activity against human SK-MEL-2 cells expressing wild type B-Raf incubated for 68 hrs by MTT assay | Homo sapiens | 3 | ALA3580536 | cell-based format | Scientific Literature | |
6. | ALA3584627 | F | Antiproliferative activity against human NZM09 cells expressing wild type B-Raf isolated from New Zealand metastatic melanoma patient incubated for 68 hrs by SRB assay | Homo sapiens | 3 | ALA3580536 | cell-based format | Scientific Literature | |
7. | ALA3584628 | F | Antiproliferative activity against human NZM40 cells expressing wild type B-Raf isolated from New Zealand metastatic melanoma patient incubated for 68 hrs by SRB assay | Homo sapiens | 3 | ALA3580536 | cell-based format | Scientific Literature | |
8. | ALA3584629 | F | Antiproliferative activity against human HT-29 cells expressing B-Raf V600E mutant incubated for 68 hrs by MTT assay | Homo sapiens | 3 | ALA3580536 | cell-based format | Scientific Literature | |
9. | ALA3584630 | F | Antiproliferative activity against human SK-MEL-1 cells expressing B-Raf V600E mutant incubated for 68 hrs by MTT assay | Homo sapiens | 3 | ALA3580536 | cell-based format | Scientific Literature | |
10. | ALA3584631 | F | Antiproliferative activity against human SK-MEL-28 cells expressing B-Raf V600E mutant incubated for 68 hrs by MTT assay | Homo sapiens | 3 | ALA3580536 | cell-based format | Scientific Literature | |
11. | ALA3584767 | F | Antiproliferative activity against human A375 cells expressing B-Raf V600E mutant incubated for 68 hrs by MTT assay | Homo sapiens | 3 | ALA3580536 | cell-based format | Scientific Literature | |
12. | ALA3584768 | F | Antiproliferative activity against human NZM20 cells expressing B-Raf V600E mutant isolated from New Zealand metastatic melanoma patient incubated for 68 hrs by SRB assay | Homo sapiens | 3 | ALA3580536 | cell-based format | Scientific Literature | |
13. | ALA3584769 | F | Antiproliferative activity against human NZM07 cells expressing B-Raf V600E mutant isolated from New Zealand metastatic melanoma patient incubated for 68 hrs by SRB assay | Homo sapiens | 3 | ALA3580536 | cell-based format | Scientific Literature | |
14. | ALA3584770 | B | Inhibition of V600E mutant in human NZM20 cells expressing B-Raf V600E mutant isolated from New Zealand metastatic melanoma patient assessed as reduction in ERK phosphorylation incubated for 2 hrs by Western blotting method | Homo sapiens | 2 | ALA3580536 | cell-based format | Scientific Literature | |
15. | ALA3584771 | B | Activation of ERK phosphorylation in human NZM40 cells expressing wild type B-Raf isolated from New Zealand metastatic melanoma patient at 0.0001 to 100 uM incubated for 2 hrs by Western blotting method | Homo sapiens | 2 | ALA3580536 | cell-based format | Scientific Literature | |
16. | ALA3584772 | B | Inhibition of V600E mutant in human COLO205 cells expressing B-Raf V600E mutant assessed as reduction in ERK phosphorylation incubated for 2 hrs by Western blotting method | Homo sapiens | 2 | ALA3580536 | cell-based format | Scientific Literature | |
17. | ALA3584773 | B | Activation of ERK phosphorylation in human HCT116 cells expressing wild type B-Raf assessed as reduction in ERK phosphorylation incubated for 2 hrs by Western blotting method | Homo sapiens | 2 | ALA3580536 | cell-based format | Scientific Literature | |
18. | ALA3584774 | A | AUC (0 to infinity) in Sprague-Dawley rat at 25 mg/kg, po | Rattus norvegicus | 1 | ALA3580536 | organism-based format | Scientific Literature | |
19. | ALA3584775 | A | Oral bioavailability in Sprague-Dawley rat at 25 mg/kg | Rattus norvegicus | 1 | ALA3580536 | organism-based format | Scientific Literature | |
20. | ALA3584776 | F | Antitumor activity against human COLO205 cells expressing B-Raf V600E mutant xenografted in SCID mouse assessed as inhibition of tumor growth at 30 to 100 mg/kg, po qd for 14 days | Homo sapiens | 1 | ALA3580536 | organism-based format | Scientific Literature |