# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3583829 | B | Inhibition of human CYP17 expressed in COS7 cells incubated for 1 hr before 17-hydroxypregnenolone substrate addition by EIA method | Homo sapiens | 4 | ALA3580617 | cell-based format | Scientific Literature | |
2. | ALA3583830 | B | Inhibition of CYP19 (unknown origin) using MFC substrate incubated for 30 mins | Homo sapiens | 4 | ALA3580617 | single protein format | Scientific Literature | |
3. | ALA3583831 | B | Inhibition of human CYP11B2 expressed in V79 cells incubated for 1 hr before 11-deoxycorticosterone substrate addition by HTRF-based assay | Homo sapiens | 37 | ALA3580617 | cell-based format | Scientific Literature | |
4. | ALA3583832 | B | Inhibition of human CYP11B1 expressed in V79 cells incubated for 1 hr before 11-deoxycortisol substrate addition by HTRF-based assay | Homo sapiens | 37 | ALA3580617 | cell-based format | Scientific Literature | |
5. | ALA3583833 | B | Selectivity index, ratio of IC50 for human CYP11B1 to IC50 for human CYP11B2 | Homo sapiens | 37 | ALA3580617 | assay format | Scientific Literature | |
6. | ALA3583834 | A | Fraction unbound in rat plasma at 2.5 mM incubated for 4 hrs by equilibrium dialysis and LC/MS method | Rattus norvegicus | 7 | ALA3580617 | cell-free format | Scientific Literature | |
7. | ALA3583835 | A | Intrinsic clearance in rat liver microsomes at 0.3 mM incubated for 10 mins before NADPH addition by LC/MS method | Rattus norvegicus | 7 | ALA3580617 | assay format | Scientific Literature | |
8. | ALA3583836 | A | Oral bioavailability in Sprague-Dawley rat at 2 mg/kg by LC-MS/MS method | Rattus norvegicus | 7 | ALA3580617 | organism-based format | Scientific Literature | |
9. | ALA3583943 | A | Dose normalized AUC in Sprague-Dawley rat at 2 mg/kg, po or 1 mg/kg, iv by LC-MS/MS method | Rattus norvegicus | 7 | ALA3580617 | organism-based format | Scientific Literature | |
10. | ALA3583944 | A | Plasma clearance in Sprague-Dawley rat at 2 mg/kg, po or 1 mg/kg, iv by LC-MS/MS method | Rattus norvegicus | 7 | ALA3580617 | organism-based format | Scientific Literature | |
11. | ALA3583945 | B | Inhibition of human CYP21 expressed in COS7 cells incubated for 1 hr before 17-hydroxypregnenolone substrate addition by HTRF-based assay | Homo sapiens | 4 | ALA3580617 | cell-based format | Scientific Literature | |
12. | ALA3583946 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 4 | ALA3580617 | single protein format | Scientific Literature | |
13. | ALA3583947 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 3 | ALA3580617 | single protein format | Scientific Literature | |
14. | ALA3583948 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 3 | ALA3580617 | single protein format | Scientific Literature | |
15. | ALA3583949 | B | Selectivity index, ratio of IC50 for CYP19 (unknown origin) to IC50 for human CYP11B2 | Homo sapiens | 4 | ALA3580617 | assay format | Scientific Literature | |
16. | ALA3583962 | B | Inhibition of rhesus monkey CYP11B2 expressed in V79 cells incubated for 1 hr before 11-deoxycorticosterone substrate addition by HTRF-based assay | Macaca mulatta | 5 | ALA3580617 | cell-based format | Scientific Literature | |
17. | ALA3583963 | B | Inhibition of rat CYP11B2 expressed in V79 cells incubated for 1 hr before 11-deoxycorticosterone substrate addition by HTRF-based assay | Rattus norvegicus | 5 | ALA3580617 | cell-based format | Scientific Literature |