# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3588429 | Binding | Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay | Rattus norvegicus | 2 | ALA3585259 | cell-based format | Scientific Literature | |
2. | ALA3588430 | Binding | Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay | Homo sapiens | 54 | ALA3585259 | cell-based format | Scientific Literature | |
3. | ALA3588431 | Binding | Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay | Mus musculus | 2 | ALA3585259 | cell-based format | Scientific Literature | |
4. | ALA3588432 | Binding | Displacement of [3H]-PGE2 from human EP1 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay | Homo sapiens | 6 | ALA3585259 | cell-based format | Scientific Literature | |
5. | ALA3588433 | Binding | Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay | Homo sapiens | 6 | ALA3585259 | cell-based format | Scientific Literature | |
6. | ALA3588434 | Binding | Displacement of [3H]-PGE2 from human EP3 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay | Homo sapiens | 6 | ALA3585259 | cell-based format | Scientific Literature | |
7. | ALA3588435 | Functional | Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production | Homo sapiens | 54 | ALA3585259 | cell-based format | Scientific Literature | |
8. | ALA3588436 | Functional | Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production | Rattus norvegicus | 2 | ALA3585259 | cell-based format | Scientific Literature | |
9. | ALA3588437 | Functional | Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production | Mus musculus | 2 | ALA3585259 | cell-based format | Scientific Literature | |
10. | ALA3588438 | ADME | Inhibition of CYP3A4 (unknown origin) at 3 uM relative to control | Homo sapiens | 19 | ALA3585259 | single protein format | Scientific Literature | |
11. | ALA3588439 | ADME | Inhibition of CYP2D6 (unknown origin) at 3 uM relative to control | Homo sapiens | 16 | ALA3585259 | single protein format | Scientific Literature | |
12. | ALA3588440 | ADME | Clearance in human liver microsomes at 10 uM by LC-MS analysis | Homo sapiens | 4 | ALA3585259 | assay format | Scientific Literature | |
13. | ALA3588441 | ADME | Clearance in rat liver microsomes at 10 uM by LC-MS analysis | Rattus norvegicus | 4 | ALA3585259 | assay format | Scientific Literature | |
14. | ALA3588442 | Binding | Selectivity ratio of IC50 for human EP1 receptor overexpressed in human ECV304 cell membranes to IC50 for human EP2 receptor overexpressed in human ECV304 cell membranes | Homo sapiens | 1 | ALA3585259 | cell-based format | Scientific Literature | |
15. | ALA3588443 | Binding | Selectivity ratio of IC50 for human EP3 receptor overexpressed in human ECV304 cell membranes to IC50 for human EP2 receptor overexpressed in human ECV304 cell membranes | Homo sapiens | 1 | ALA3585259 | cell-based format | Scientific Literature | |
16. | ALA3588444 | Binding | Selectivity ratio of IC50 for human EP4 receptor overexpressed in human ECV304 cell membranes to IC50 for human EP2 receptor overexpressed in human ECV304 cell membranes | Homo sapiens | 5 | ALA3585259 | cell-based format | Scientific Literature | |
17. | ALA3588448 | ADME | Drug metabolism in human liver microsomes at 10 uM by LC-MS/reverse phase HPLC analysis | Homo sapiens | 1 | ALA3585259 | assay format | Scientific Literature | |
18. | ALA3588449 | ADME | Drug metabolism in rat liver microsomes at 10 uM by LC-MS/reverse phase HPLC analysis | Rattus norvegicus | 1 | ALA3585259 | assay format | Scientific Literature |