# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3587000 | F | In vivo activation of Nrf2 in LPS-stimulated C57BL/6 mouse lung at 10 to 80 mg/kg/day, ip pretreated for 48 hrs followed by LPS challenge measured after 5 hrs by DAPI staining-based laser scanning confocal microscopic analysis | Mus musculus | 1 | ALA3585308 | organism-based format | Scientific Literature | |
2. | ALA3587002 | F | In vivo activation of Nrf2 in LPS-stimulated ip dosed C57BL/6 mouse lung pretreated for 48 hrs followed by LPS challenge measured after 5 hrs by Western blot analysis | Mus musculus | 1 | ALA3585308 | organism-based format | Scientific Literature | |
3. | ALA3588496 | B | Activation of Nrf2 in human HepG2-ARE-C8 cells assessed as upregulation of ARE level at 20 uM after 12 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 43 | ALA3585308 | cell-based format | Scientific Literature | |
4. | ALA3588498 | B | Activation of Nrf2 in human HepG2-ARE-C8 cells assessed as upregulation of ARE level at 0.2 uM after 12 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 43 | ALA3585308 | cell-based format | Scientific Literature | |
5. | ALA3588499 | B | Activation of Nrf2 in human HepG2-ARE-C8 cells assessed as upregulation of ARE level at 0.02 uM after 12 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 43 | ALA3585308 | cell-based format | Scientific Literature | |
6. | ALA3588500 | B | Activation of Nrf2 in human HepG2-ARE-C8 cells assessed as upregulation of ARE level at 2 uM after 12 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 43 | ALA3585308 | cell-based format | Scientific Literature | |
7. | ALA3587109 | B | Activation of Nrf2 in human HepG2-ARE-C8 cells assessed as upregulation of ARE level at 40 uM after 12 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 43 | ALA3585308 | cell-based format | Scientific Literature | |
8. | ALA3587110 | B | Activation of Nrf2 in human HepG2-ARE-C8 cells assessed as upregulation of ARE level at 80 uM after 12 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 43 | ALA3585308 | cell-based format | Scientific Literature | |
9. | ALA3587111 | B | Activation of Nrf2 in human HepG2-ARE-C8 cells assessed as upregulation of ARE level at 160 uM after 12 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 43 | ALA3585308 | cell-based format | Scientific Literature | |
10. | ALA3587122 | B | Activation of Nrf2 in human HCT116 cells measured at 4 hrs by qRT-PCR analysis | Homo sapiens | 2 | ALA3585308 | cell-based format | Scientific Literature | |
11. | ALA3587123 | B | Activation of Nrf2 in human HCT116 cells assessed as upregulation of GCLM gene expression measured at 4 hrs by qRT-PCR analysis | Homo sapiens | 2 | ALA3585308 | cell-based format | Scientific Literature | |
12. | ALA3587124 | B | Activation of Nrf2 in human HCT116 cells assessed as upregulation of HO-1 gene expression measured at 4 hrs by qRT-PCR analysis | Homo sapiens | 2 | ALA3585308 | cell-based format | Scientific Literature | |
13. | ALA3587129 | A | Cytotoxicity against human HCT116 cells assessed as reduction of cell proliferation at 80 uM after 24 hrs by MTT assay | Homo sapiens | 37 | ALA3585308 | cell-based format | Scientific Literature | |
14. | ALA3587130 | B | Activation of Nrf2 in human HepG2-ARE-C8 cells assessed as upregulation of ARE level after 12 hrs by luciferase reporter gene assay | Homo sapiens | 1 | ALA3585308 | cell-based format | Scientific Literature | |
15. | ALA3587131 | P | Dissociation constant, pKa of the compound by potentiometric titration method | 7 | ALA3585308 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA3587132 | P | Lipophilicity, log D of the compound at pH 7.4 by potentiometric titration method | 7 | ALA3585308 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA3587133 | P | Intrinsic aqueous solubility of the compound by potentiometric titration method | 7 | ALA3585308 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA3587134 | P | Permeability of the compound at pH 7.4 by PAMPA | 9 | ALA3585308 | small-molecule physicochemical format | Scientific Literature | ||
19. | ALA3587135 | B | Induction of Nrf2 phosphorylation at S40 in cytoplasm of human HCT116 cells at 20 uM after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA3585308 | cell-based format | Scientific Literature | |
20. | ALA3587136 | B | Induction of Nrf2 translocation from cytoplasm to nucleus in human HCT116 cells at 20 uM after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA3585308 | cell-based format | Scientific Literature |