| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3592701 | B | Inhibition of human wild-type beta-catenin (residues 138-686)/C-terminally fluorescein labeled human wild-type Tcf4 (residues 7-51) interaction after 1.5 hrs by FP competitive inhibition assay | Homo sapiens | 34 | ALA3588842 | single protein format | Scientific Literature | |
| 2. | ALA3592702 | B | Inhibition of N-terminally His6-tagged human beta-catenin (residues 138-686)/C-terminally biotinylated human Tcf4 (residues 7-51) interaction after 45 mins by AlphaScreen competitive inhibition assay | Homo sapiens | 21 | ALA3588842 | single protein format | Scientific Literature | |
| 3. | ALA3592703 | B | Inhibition of interaction of beta-catenin (unknown origin) transfected in Wnt-activated HEK293 cells/Tcf4 assessed as decrease in transactivation of canonical Wnt signaling by TOPflash luciferase reporter assay | Homo sapiens | 11 | ALA3588842 | cell-based format | Scientific Literature | |
| 4. | ALA3592707 | F | Cytotoxicity against human SW480 cells assessed as inhibition of cell growth after 72 hrs by MTS assay | Homo sapiens | 12 | ALA3588842 | cell-based format | Scientific Literature | |
| 5. | ALA3592708 | F | Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth after 72 hrs by MTS assay | Homo sapiens | 12 | ALA3588842 | cell-based format | Scientific Literature | |
| 6. | ALA3592710 | F | Decrease in AXIN2 mRNA expression in human SW480 cells after 24 hrs by quantitative real-time PCR analysis | Homo sapiens | 2 | ALA3588842 | cell-based format | Scientific Literature | |
| 7. | ALA3592711 | F | Decrease in cyclin D1 mRNA expression in human SW480 cells after 24 hrs by quantitative real-time PCR analysis | Homo sapiens | 2 | ALA3588842 | cell-based format | Scientific Literature | |
| 8. | ALA3592712 | F | Decrease in c-myc mRNA expression in human SW480 cells after 24 hrs by quantitative real-time PCR analysis | Homo sapiens | 2 | ALA3588842 | cell-based format | Scientific Literature | |
| 9. | ALA3592832 | F | Effect on HPRT mRNA expression in human SW480 cells after 24 hrs by quantitative real-time PCR analysis | Homo sapiens | 2 | ALA3588842 | cell-based format | Scientific Literature | |
| 10. | ALA3592841 | B | Inhibition of human beta-catenin V511S mutant/human wild-type Tcf4 interaction after 1.5 hrs by FP competitive inhibition assay | Homo sapiens | 4 | ALA3588842 | single protein format | Scientific Literature | |
| 11. | ALA3592842 | B | Inhibition of human beta-catenin V511S/I569S double mutant/human wild-type Tcf4 interaction after 1.5 hrs by FP competitive inhibition assay | Homo sapiens | 1 | ALA3588842 | single protein format | Scientific Literature | |
| 12. | ALA3592843 | B | Inhibition of human beta-catenin R469A mutant/human wild-type Tcf4 interaction after 1.5 hrs by FP competitive inhibition assay | Homo sapiens | 4 | ALA3588842 | single protein format | Scientific Literature | |
| 13. | ALA3592844 | B | Inhibition of beta-catenin (unknown origin) transfected in Wnt-activated HEK293 cells interaction with Tcf4 assessed as decrease in transactivation of canonical Wnt signaling at 200 uM by FOPflash luciferase reporter assay | Homo sapiens | 4 | ALA3588842 | cell-based format | Scientific Literature | |
| 14. | ALA3592845 | B | Inhibition of human wild-type beta-catenin (residues 138-686)/C-terminally fluorescein-labeled human E-cadherin (residues 819-873) interaction by FP competitive inhibition assay | Homo sapiens | 11 | ALA3588842 | single protein format | Scientific Literature | |
| 15. | ALA3592846 | B | Inhibition of human wild-type beta-catenin (residues 138-686)/C-terminally fluorescein-labeled human APC-R3 (residues 1477-1519) interaction by FP competitive inhibition assay | Homo sapiens | 11 | ALA3588842 | single protein format | Scientific Literature | |
| 16. | ALA5227380 | B | Inhibition of Wnt/beta-catenin signaling pathway in human COLO 320DM cells assessed as reduction in AXIN2 | Homo sapiens | 5 | ALA5226302 | cell-based format | Scientific Literature | |
| 17. | ALA5227381 | B | Inhibition of beta-catenin/E-cad signaling pathway in human COLO 320DM cells assessed as reduction in AXIN2 | Homo sapiens | 4 | ALA5226302 | cell-based format | Scientific Literature | |
| 18. | ALA5227382 | B | Binding affinity to beta catenin (unknown origin) assessed as inhibition constant by alpha screen assay | Homo sapiens | 4 | ALA5226302 | single protein format | Scientific Literature | |
| 19. | ALA5236762 | F | Antiproliferative activity against human SW480 cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay | Homo sapiens | 2 | ALA5236544 | cell-based format | Scientific Literature | |
| 20. | ALA5236763 | F | Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay | Homo sapiens | 3 | ALA5236544 | cell-based format | Scientific Literature |
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