# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3592565 | F | Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay | Homo sapiens | 12 | ALA3588779 | cell-based format | Scientific Literature | |
2. | ALA3592680 | F | Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay | Homo sapiens | 12 | ALA3588779 | cell-based format | Scientific Literature | |
3. | ALA3592681 | F | Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay relative to fMLF | Homo sapiens | 2 | ALA3588779 | cell-based format | Scientific Literature | |
4. | ALA3592682 | F | Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay relative to WKYMVm | Homo sapiens | 8 | ALA3588779 | cell-based format | Scientific Literature | |
5. | ALA3592683 | F | Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid | Homo sapiens | 12 | ALA3588779 | single protein format | Scientific Literature | |
6. | ALA3592684 | F | Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid | Homo sapiens | 12 | ALA3588779 | single protein format | Scientific Literature | |
7. | ALA3592685 | F | Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay relative to fMLF in absence of probenecid | Homo sapiens | 6 | ALA3588779 | single protein format | Scientific Literature | |
8. | ALA3592686 | F | Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay relative to fMLF in presence of probenecid | Homo sapiens | 8 | ALA3588779 | single protein format | Scientific Literature | |
9. | ALA3592687 | F | Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay | Mus musculus | 12 | ALA3588779 | single protein format | Scientific Literature | |
10. | ALA3592688 | F | Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay relative to fMLF | Mus musculus | 12 | ALA3588779 | single protein format | Scientific Literature | |
11. | ALA3592689 | A | Half life in rat liver microsomes at 1 uM preincubated for 10 mins followed by addition of NADPH regenerating system by LC-MS analysis | Rattus norvegicus | 8 | ALA3588779 | assay format | Scientific Literature | |
12. | ALA3592690 | A | Intrinsic clearance in rat liver microsomes at 1 uM preincubated for 10 mins followed by addition of NADPH regenerating system by LC-MS analysis | Rattus norvegicus | 8 | ALA3588779 | assay format | Scientific Literature | |
13. | ALA4135886 | F | Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization | Homo sapiens | 2 | ALA4130539 | cell-based format | Scientific Literature | |
14. | ALA4135888 | F | Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization | Homo sapiens | 1 | ALA4130539 | cell-based format | Scientific Literature | |
15. | ALA4135891 | F | Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization | Homo sapiens | 1 | ALA4130539 | assay format | Scientific Literature | |
16. | ALA4135892 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 10 uM preincubated for 10 mins followed by NADPH addition measured after 30 mins by liquid chromatographic method | Rattus norvegicus | 25 | ALA4130539 | microsome format | Scientific Literature |