| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3599997 | B | Inhibition of recombinant mouse RANKL-induced osteoclastogenesis of mouse RAW264.7 cells assessed as reduction of TRAP-positive multinucleated cells at 5 uM after 4 days by light microscopic analysis relative to control | Mus musculus | 12 | cell-based format | Scientific Literature | ||
| 2. | ALA3599998 | A | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 5 uM after 24 hrs by MTT assay relative to control | Mus musculus | 12 | cell-based format | Scientific Literature | ||
| 3. | ALA3599999 | B | Inhibition of recombinant mouse RANKL-induced TRAP activity in mouse RAW264.7 cells using 4-nitrophenyl phosphate as TRAP substrate preincubated for 4 days followed by substrate addition measured after 15 mins by ELISA reader analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA3600000 | B | Inhibition of recombinant mouse RANKL-induced osteoclastogenesis of mouse RAW264.7 cells assessed as suppression of NFATc1 mRNA expression at 2.5 to 5 uM preincubated for 1 hr followed by RANKL addition measured after 24 hrs by RT-PCR analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA3600001 | B | Inhibition of recombinant mouse RANKL-induced osteoclastogenesis of mouse RAW264.7 cells assessed as suppression of c-fos mRNA expression at 2.5 to 5 uM preincubated for 1 hr followed by RANKL addition measured after 24 hrs by RT-PCR analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA3600002 | B | Inhibition of recombinant mouse RANKL-induced osteoclastogenesis of mouse RAW264.7 cells assessed as suppression of TRAP mRNA expression at 2.5 to 5 uM preincubated for 1 hr followed by RANKL addition measured after 24 hrs by RT-PCR analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA3600003 | B | Inhibition of recombinant mouse RANKL-induced osteoclastogenesis of mouse RAW264.7 cells assessed as suppression of cathepsin K mRNA expression at 2.5 to 5 uM preincubated for 1 hr followed by RANKL addition measured after 24 hrs by RT-PCR analysis | Mus musculus | 2 | cell-based format | Scientific Literature |
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