# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3599913 | B | Displacement of [3H]MPEP from mGluR5 receptor in Sprague-Dawley rat forebrain membrane after 60 mins by liquid scintillation spectrometry | Rattus norvegicus | 22 | ALA3596098 | assay format | Scientific Literature | |
2. | ALA3599914 | B | Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometry | Homo sapiens | 24 | ALA3596098 | cell-based format | Scientific Literature | |
3. | ALA3599915 | F | Negative allosteric modulatory activity at human cloned mGluR5 receptor expressed in CHO-T-Rex cells assessed as inhibiton of quisqualate-induced calcium mobilization treated 10 mins prior to agonist application by fluorescence analysis | Homo sapiens | 16 | ALA3596098 | cell-based format | Scientific Literature | |
4. | ALA3599916 | B | Displacement of [3H]R214127 from rat cloned mGluR1 receptor expressed in CHO-T-Rex cells after 30 mins by liquid scintillation spectrometry | Rattus norvegicus | 18 | ALA3596098 | cell-based format | Scientific Literature | |
5. | ALA3600045 | F | Negative allosteric modulatory activity at rat cloned mGluR1 receptor expressed in CHO-T-Rex cells assessed as inhibiton of quisqualate-induced calcium mobilization treated 10 mins prior to agonist application by fluorescence analysis | Rattus norvegicus | 7 | ALA3596098 | cell-based format | Scientific Literature | |
6. | ALA3600046 | F | Non-competitive antagonist activity at human cloned mGluR5 receptor expressed in CHO-T-Rex cells assessed as inhibiton of quisqualate-induced calcium mobilization at 0.3 nM treated 10 mins prior to agonist application by fluorescence analysis | Homo sapiens | 1 | ALA3596098 | cell-based format | Scientific Literature | |
7. | ALA4413470 | B | Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysis | Homo sapiens | 52 | ALA4411314 | cell-based format | Scientific Literature | |
8. | ALA4413471 | B | Displacement of [3H]MPEP from rat mGlu1 receptor expressed in CHO-TREx cell membranes after 30 mins by liquid scintillation spectrometric analysis | Rattus norvegicus | 47 | ALA4411314 | cell-based format | Scientific Literature | |
9. | ALA4413472 | P | Kinetic solubility of compound in Tris-HCl buffer at pH 7.4 at 1 mM after 4 hrs by HPLC analysis | 27 | ALA4411314 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4413473 | F | Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobilization incubated for 18 hrs and measured every 1.5 secs intervals for 60 secs by Fluo-4/AM dye-based fluorescence analysis | Homo sapiens | 31 | ALA4411314 | cell-based format | Scientific Literature | |
11. | ALA4413474 | A | Inhibition of recombinant human CYP1A2 using 3-cyano-7-ethoxycoumarin as substrate preincubated for 10 mins followed by substrate addition and measured after 15 mins | Homo sapiens | 30 | ALA4411314 | single protein format | Scientific Literature | |
12. | ALA4413475 | A | Inhibition of recombinant human CYP2D6 using 3-[2-(N,N-diethylamino)ethyl]-7-methoxy-4-methylcoumarin as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins | Homo sapiens | 38 | ALA4411314 | single protein format | Scientific Literature | |
13. | ALA4413476 | A | Inhibition of recombinant human CYP3A4 using 7-benzyloxy-trifluoromethylcoumarin as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins | Homo sapiens | 38 | ALA4411314 | single protein format | Scientific Literature | |
14. | ALA4413482 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 0.2 mM after 30 mins in presence of NADPH by HPLC-MS/MS analysis | Rattus norvegicus | 32 | ALA4411314 | microsome format | Scientific Literature | |
15. | ALA4413483 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 0.2 mM after 30 mins in presence of NADPH by HPLC-MS/MS analysis | Homo sapiens | 32 | ALA4411314 | microsome format | Scientific Literature |