# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3599260 | F | Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay | Homo sapiens | 36 | ALA3596134 | cell-based format | Scientific Literature | |
2. | ALA3599261 | F | Antagonist activity at human CysLT2 expressed in HEK293 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay | Homo sapiens | 36 | ALA3596134 | cell-based format | Scientific Literature | |
3. | ALA3599264 | P | Apparent permeability of the compound at 50 uM at pH 7.4 after 4 hrs by PAMPA | 30 | ALA3596134 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA3599268 | F | Antiasthmatic activity in guinea pig assessed as inhibition of LTD4-induced bronchoconstriction at 0.3 mg/kg, po administered 1 hr prior to LTD4 challenge measured over 10 mins relative to control | Cavia porcellus | 10 | ALA3596134 | organism-based format | Scientific Literature | |
5. | ALA3599284 | F | Antiasthmatic activity in guinea pig assessed as inhibition of LTD4-induced bronchoconstriction at 1 mg/kg, po administered 24 hrs prior to LTD4 challenge measured over 10 mins relative to control | Cavia porcellus | 2 | ALA3596134 | organism-based format | Scientific Literature | |
6. | ALA3599285 | A | AUC in guinea pig at 0.2 mg/kg, iv and 1 mg/kg, po administered as cassette dosing | Cavia porcellus | 2 | ALA3596134 | organism-based format | Scientific Literature | |
7. | ALA3599286 | A | Oral bioavailability in guinea pig at 1 mg/kg administered as cassette dosing | Cavia porcellus | 3 | ALA3596134 | organism-based format | Scientific Literature | |
8. | ALA3599287 | F | Antagonist activity at guinea pig CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay | Cavia porcellus | 6 | ALA3596134 | cell-based format | Scientific Literature | |
9. | ALA3599288 | F | Antagonist activity at guinea pig CysLT2 expressed in CHOK1 cells assessed as inhibition of LTC4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay | Cavia porcellus | 6 | ALA3596134 | cell-based format | Scientific Literature | |
10. | ALA3599289 | F | Antiasthmatic activity in guinea pig assessed as inhibition of LTD4-induced bronchoconstriction at 0.3 mg/kg, po administered 24 hrs prior to LTD4 challenge measured over 10 mins relative to control | Cavia porcellus | 6 | ALA3596134 | organism-based format | Scientific Literature | |
11. | ALA3599290 | F | Antiasthmatic activity in guinea pig assessed as inhibition of LTD4-induced bronchoconstriction at 0.1 mg/kg, po administered 24 hrs prior to LTD4 challenge measured over 10 mins relative to control | Cavia porcellus | 5 | ALA3596134 | organism-based format | Scientific Literature | |
12. | ALA3599408 | P | Stability of the compound in H2SO4/DME/H2O at 50 degC measured for 24 hrs | 1 | ALA3596134 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA3599409 | P | Stability of the compound in NaOH/DME/EtOH/H2O at 50 degC measured for 24 hrs | 1 | ALA3596134 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA3599410 | P | Stability of the compound in ambient light | 2 | ALA3596134 | small-molecule physicochemical format | Scientific Literature |