# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3599260 | F | Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
2. | ALA3599261 | F | Antagonist activity at human CysLT2 expressed in HEK293 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
3. | ALA3599268 | F | Antiasthmatic activity in guinea pig assessed as inhibition of LTD4-induced bronchoconstriction at 0.3 mg/kg, po administered 1 hr prior to LTD4 challenge measured over 10 mins relative to control | Cavia porcellus | 10 | organism-based format | Scientific Literature | ||
4. | ALA3599284 | F | Antiasthmatic activity in guinea pig assessed as inhibition of LTD4-induced bronchoconstriction at 1 mg/kg, po administered 24 hrs prior to LTD4 challenge measured over 10 mins relative to control | Cavia porcellus | 2 | organism-based format | Scientific Literature | ||
5. | ALA3599285 | A | AUC in guinea pig at 0.2 mg/kg, iv and 1 mg/kg, po administered as cassette dosing | Cavia porcellus | 2 | organism-based format | Scientific Literature | ||
6. | ALA3599286 | A | Oral bioavailability in guinea pig at 1 mg/kg administered as cassette dosing | Cavia porcellus | 3 | organism-based format | Scientific Literature | ||
7. | ALA3599287 | F | Antagonist activity at guinea pig CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay | Cavia porcellus | 6 | cell-based format | Scientific Literature | ||
8. | ALA3599288 | F | Antagonist activity at guinea pig CysLT2 expressed in CHOK1 cells assessed as inhibition of LTC4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay | Cavia porcellus | 6 | cell-based format | Scientific Literature | ||
9. | ALA3599289 | F | Antiasthmatic activity in guinea pig assessed as inhibition of LTD4-induced bronchoconstriction at 0.3 mg/kg, po administered 24 hrs prior to LTD4 challenge measured over 10 mins relative to control | Cavia porcellus | 6 | organism-based format | Scientific Literature |