| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3602662 | B | Displacement of [3H]-1-MeHis-TRH from mouse TRH-R1 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting method | Mus musculus | 18 | ALA3600362 | cell-based format | Scientific Literature | |
| 2. | ALA3602663 | B | Displacement of [3H]-1-MeHis-TRH from mouse TRH-R2 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting method | Mus musculus | 18 | ALA3600362 | cell-based format | Scientific Literature | |
| 3. | ALA3602664 | F | Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR method | Mus musculus | 18 | ALA3600362 | cell-based format | Scientific Literature | |
| 4. | ALA3602665 | F | Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR method | Mus musculus | 18 | ALA3600362 | cell-based format | Scientific Literature | |
| 5. | ALA3602666 | B | Selectivity index, ratio of EC50 for agonist activity at mouse TRH-R1 expressed in HEK293 cells to EC50 for agonist activity at mouse TRH-R2 expressed in HEK293 cells | Mus musculus | 18 | ALA3600362 | cell-based format | Scientific Literature | |
| 6. | ALA3602667 | F | Reduction in pentobarbital-induced sleeping time in Swiss mouse at 10 umol/kg, iv | Mus musculus | 18 | ALA3600362 | organism-based format | Scientific Literature | |
| 7. | ALA3602668 | A | Plasma concentration in Sprague-Dawley rat assessed as TSH level at 10 umol/kg, iv after 15 mins by ELISA method (Rvb = 4.56 ng/ml) | Rattus norvegicus | 1 | ALA3600362 | organism-based format | Scientific Literature | |
| 8. | ALA3602669 | A | Plasma concentration in Sprague-Dawley rat assessed as TSH level at 10 umol/kg, iv after 30 mins by ELISA method (Rvb = 4.56 ng/ml) | Rattus norvegicus | 1 | ALA3600362 | organism-based format | Scientific Literature | |
| 9. | ALA3602670 | A | Plasma concentration in Sprague-Dawley rat assessed as TSH level at 10 umol/kg, iv after 45 mins by ELISA method (Rvb = 4.56 ng/ml) | Rattus norvegicus | 1 | ALA3600362 | organism-based format | Scientific Literature | |
| 10. | ALA3602675 | A | Stability assessed as mouse recombinant TRH-degrading ectoenzyme-mediated compound degradation up to 18 hrs by HPLC method | Mus musculus | 1 | ALA3600362 | single protein format | Scientific Literature | |
| 11. | ALA3602676 | F | Reduction in volume of infarction in Sprague-Dawley rat model of MCA occlusion-induced focal cerebral ischemia assessed as infarcts volume at 10 umol/kg, iv administered immediately after reperfusion and measured 22 hrs after reperfusion (Rvb = 237.69 +/- 4.08 mm3) | Rattus norvegicus | 1 | ALA3600362 | organism-based format | Scientific Literature | |
| 12. | ALA3602677 | F | Reduction in neurological score in Sprague-Dawley rat model of MCA occlusion-induced focal cerebral ischemia at 10 umol/kg, iv administered immediately after reperfusion and measured 22 hrs after reperfusion up to 7 days | Rattus norvegicus | 1 | ALA3600362 | organism-based format | Scientific Literature | |
| 13. | ALA3602706 | A | Effect on mean latency time during acquisition trial in Sprague-Dawley rat model of MCA occlusion-induced memory impairment at 10 umol/kg, iv by passive avoidance test | Rattus norvegicus | 1 | ALA3600362 | organism-based format | Scientific Literature | |
| 14. | ALA3602707 | F | Effect on mean latency time during retention trial in Sprague-Dawley rat model of MCA occlusion-induced memory impairment at 10 umol/kg, iv by passive avoidance test | Rattus norvegicus | 1 | ALA3600362 | organism-based format | Scientific Literature | |
| 15. | ALA3602708 | F | Reduction in cognitive impairment in Sprague-Dawley rat assessed as increase in number of entries to platform zone during retention trial at 10 umol/kg, iv measured on day 6 by Morris water maze test (Rvb = 0.5 No_unit) | Rattus norvegicus | 1 | ALA3600362 | organism-based format | Scientific Literature | |
| 16. | ALA3602709 | F | Reduction in cognitive impairment in Sprague-Dawley rat assessed as reduction in latency to first entry to platform zone during retention trial at 10 umol/kg, iv measured on day 6 by Morris water maze test (Rvb = 95.76 secs) | Rattus norvegicus | 1 | ALA3600362 | organism-based format | Scientific Literature | |
| 17. | ALA3602710 | F | Inhibition of lipid peroxidation in brain homogenates of Sprague-Dawley rat model of 2 hrs MCA occlusion-induced focal cerebral ischemia assessed as reduction in MDA levels at 10 umol/kg, iv administered immediately after reperfusion and measured 22 hrs after reperfusion by TBARS assay | Rattus norvegicus | 1 | ALA3600362 | organism-based format | Scientific Literature | |
| 18. | ALA3602711 | F | Increase in neuronal survival in Sprague-Dawley rat model of MCA occlusion-induced focal cerebral ischemia assessed as increase in neuronal density at hippocampal CA1 regions at 10 umol/kg, iv by Cresyl violet staining based microscopy | Rattus norvegicus | 1 | ALA3600362 | organism-based format | Scientific Literature | |
| 19. | ALA3602712 | F | Neuroprotective activity in Sprague-Dawley rat model of MCA occlusion-induced memory impairment assessed as maximum latency time during acquisition trial at 10 umol/kg, iv by passive avoidance test (Rvb = 49 secs) | Rattus norvegicus | 1 | ALA3600362 | organism-based format | Scientific Literature | |
| 20. | ALA3602713 | F | Neuroprotective activity in Sprague-Dawley rat model of MCA occlusion-induced memory impairment assessed as minimum latency time during acquisition trial at 10 umol/kg, iv by passive avoidance test (Rvb = 49 secs) | Rattus norvegicus | 1 | ALA3600362 | organism-based format | Scientific Literature |
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