# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3603311 | Binding | Inhibition of TTK (unknown origin) by LanthaScreen assay | Homo sapiens | 6 | ALA3600288 | single protein format | Scientific Literature | |
2. | ALA3603318 | Binding | Inhibition of JAK1 (unknown origin) by Z'-Lyte assay | Homo sapiens | 7 | ALA3600288 | single protein format | Scientific Literature | |
3. | ALA3603319 | Binding | Inhibition of JAK2 (unknown origin) by Z'-Lyte assay | Homo sapiens | 7 | ALA3600288 | single protein format | Scientific Literature | |
4. | ALA3603320 | Binding | Inhibition of TYK2 (unknown origin) by Z'-Lyte assay | Homo sapiens | 4 | ALA3600288 | single protein format | Scientific Literature | |
5. | ALA3603326 | Binding | Inhibition of JAK3 (unknown origin) by Z'-Lyte assay | Homo sapiens | 72 | ALA3600288 | single protein format | Scientific Literature | |
6. | ALA3603327 | Functional | Antiproliferative activity against mouse BA/F3 cells expressing TEL-JAK1 after 72 hrs by cell titer glo assay | Mus musculus | 65 | ALA3600288 | cell-based format | Scientific Literature | |
7. | ALA3603328 | Functional | Antiproliferative activity against mouse BA/F3 cells expressing TEL-JAK2 after 72 hrs by cell titer glo assay | Mus musculus | 65 | ALA3600288 | cell-based format | Scientific Literature | |
8. | ALA3603329 | Functional | Antiproliferative activity against mouse BA/F3 cells expressing TEL-JAK3 after 72 hrs by cell titer glo assay | Mus musculus | 71 | ALA3600288 | cell-based format | Scientific Literature | |
9. | ALA3603330 | Functional | Antiproliferative activity against mouse BA/F3 cells expressing TYK2 E957D mutant after 72 hrs by cell titer glo assay | Mus musculus | 64 | ALA3600288 | cell-based format | Scientific Literature | |
10. | ALA3603331 | Functional | Antiproliferative activity against mouse BA/F3 cells expressing TEL-ABL after 72 hrs by cell titer glo assay | Mus musculus | 64 | ALA3600288 | cell-based format | Scientific Literature | |
11. | ALA3603332 | ADME | Half life in mouse liver microsomes | Mus musculus | 34 | ALA3600288 | assay format | Scientific Literature | |
12. | ALA3602072 | Binding | Inhibition of JAK3 (unknown origin) expressed in mouse BA/F3 cells assessed as reduction of STAT5 phosphorylation at 100 nM after 3 hrs by immunoblotting analysis | Homo sapiens | 2 | ALA3600288 | cell-based format | Scientific Literature | |
13. | ALA3602073 | Binding | Inhibition of JAK3 (unknown origin) expressed in mouse BA/F3 cells assessed as reduction of STAT5 phosphorylation at 300 nM incubated for 3 hrs followed by washout measured after 4 hrs by immunoblotting analysis | Homo sapiens | 4 | ALA3600288 | cell-based format | Scientific Literature | |
14. | ALA3602076 | Binding | Inhibition of JAK3 (unknown origin) expressed in mouse BA/F3 cells at 300 nM preincubated for 3 hrs followed by pulldown with streptavidin beads by immunoblotting analysis | Homo sapiens | 2 | ALA3600288 | cell-based format | Scientific Literature | |
15. | ALA3602077 | Binding | Irreversible inhibition of recombinant JAK3 kinase domain (unknown origin) assessed as addition of expected molecular weight by electrospray ionization mass spectrometry analysis | Homo sapiens | 3 | ALA3600288 | single protein format | Scientific Literature | |
16. | ALA3602078 | Binding | Inhibition of JAK3 in mouse BMDM assessed as inhibition of IL-4 induced STAT6 phosphorylation at 500 nM preincubated for 3 hrs followed by IL-4 induction measured after 30 mins by immunoblotting | Mus musculus | 3 | ALA3600288 | single protein format | Scientific Literature | |
17. | ALA3602079 | Binding | Inhibition of JAK1 in mouse BMDM assessed as inhibition of IFNbeta-induced STAT1 phosphorylation at 5 uM preincubated for 3 hrs followed by IFNbeta induction measured after 30 mins by immunoblotting | Mus musculus | 3 | ALA3600288 | single protein format | Scientific Literature | |
18. | ALA3602080 | Binding | Inhibition of JAK2 in mouse BMDM assessed as inhibition of GM-CSF-induced STAT5 phosphorylation at 5 uM preincubated for 3 hrs followed by GM-CSF induction measured after 30 mins by immunoblotting | Mus musculus | 3 | ALA3600288 | single protein format | Scientific Literature | |
19. | ALA3602081 | Binding | Inhibition of TYK2 in mouse BMDM assessed as inhibition of IL-10-induced STAT3 phosphorylation at 5 uM preincubated for 3 hrs followed by IL-4 induction measured after 30 mins by immunoblotting | Mus musculus | 3 | ALA3600288 | single protein format | Scientific Literature | |
20. | ALA3602082 | Binding | Inhibition of JAK3 in mouse BMDM assessed as inhibition of IL-4 induced STAT6 phosphorylation at 10 uM incubated for 3 hrs prior to compound washout for 8 to 24 hrs and followed by IL-4 induction measured after 30 mins by immunoblotting | Mus musculus | 2 | ALA3600288 | single protein format | Scientific Literature |