# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3607815 | F | Antitrypanosomal activity against bloodstream forms of Trypanosoma brucei rhodesiense STIB 900 after 72 hrs by alamar blue assay | Trypanosoma brucei rhodesiense | 29 | ALA3603776 | organism-based format | Scientific Literature | |
2. | ALA3607816 | T | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for bloodstream forms of Trypanosoma brucei rhodesiense STIB 900 | 29 | ALA3603776 | cell-based format | Scientific Literature | ||
3. | ALA3606212 | F | Antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi Tulahuen C4 expressing LacZ gene infected in rat L6 cells after 96 hrs by inverted microscope analysis | Trypanosoma cruzi | 29 | ALA3603776 | organism-based format | Scientific Literature | |
4. | ALA3606214 | F | Antitrypanosomal activity against amastigotes of Leishmania donovani MHOM/ET/67/L82 after 72 hrs by inverted microscope analysis | Leishmania donovani | 29 | ALA3603776 | organism-based format | Scientific Literature | |
5. | ALA3606215 | T | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for amastigotes of Leishmania donovani MHOM/ET/67/L82 | 29 | ALA3603776 | cell-based format | Scientific Literature | ||
6. | ALA3606216 | A | Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay | Rattus norvegicus | 33 | ALA3603776 | cell-based format | Scientific Literature | |
7. | ALA3606217 | B | Inhibition of recombinant Trypanosoma brucei GAPDH assessed as oxidative phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate at 5 uM by spectrophotometric method relative to 2-phenoxy-1,4-naphthoquinone | Trypanosoma brucei | 29 | ALA3603776 | assay format | Scientific Literature | |
8. | ALA3606218 | B | Inhibition of electron transport protein complex 1 in bovine hear mitochondria assessed as enzyme activity per min/mg of protein using NADPH as substrate at 10 uM | Bos taurus | 4 | ALA3603776 | mitochondrion format | Scientific Literature | |
9. | ALA3606219 | B | Inhibition of recombinant Trypanosoma brucei GAPDH assessed as oxidative phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate by spectrophotometric method | Trypanosoma brucei | 4 | ALA3603776 | assay format | Scientific Literature | |
10. | ALA3606220 | B | Inhibition of recombinant human GAPDH assessed as oxidative phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate by spectrophotometric method | Homo sapiens | 4 | ALA3603776 | single protein format | Scientific Literature | |
11. | ALA3606221 | A | Cytotoxicity against HDF after 24 hrs by MTT assay | Homo sapiens | 4 | ALA3603776 | assay format | Scientific Literature | |
12. | ALA3606222 | F | Cytotoxicity against human IGROV1 cells after 24 hrs by MTT assay | Homo sapiens | 4 | ALA3603776 | cell-based format | Scientific Literature | |
13. | ALA3606223 | F | Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay | Homo sapiens | 4 | ALA3603776 | cell-based format | Scientific Literature | |
14. | ALA3606224 | U | Selectivity index, ratio of IC50 for HDF to IC50 for human IGROV1 cells | Homo sapiens | 4 | ALA3603776 | cell-based format | Scientific Literature | |
15. | ALA3606225 | U | Selectivity index, ratio of IC50 for HDF to IC50 for human HT-29 cells | Homo sapiens | 4 | ALA3603776 | cell-based format | Scientific Literature | |
16. | ALA3606226 | B | Inhibition of electron transport protein complex 1 in bovine hear mitochondria assessed as reduction of NADH-induced oxygen consumption at 5 uM | Bos taurus | 3 | ALA3603776 | mitochondrion format | Scientific Literature | |
17. | ALA3606228 | B | Inhibition of electron transport protein complex 2 in bovine hear mitochondria assessed as reduction of succinate-induced oxygen consumption at 5 uM | Bos taurus | 28 | ALA3603776 | mitochondrion format | Scientific Literature | |
18. | ALA3606229 | B | Inhibition of electron transport protein complex 1 in bovine hear mitochondria assessed as reduction of NADH-induced ROS production at 10 uM by fluorescence plate reader analysis | Bos taurus | 4 | ALA3603776 | mitochondrion format | Scientific Literature |