| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3608014 | B | Binding affinity to human recombinant sGC catalytic subunit by surface plasmon resonance analysis | Homo sapiens | 17 | protein complex format | Scientific Literature | ||
| 2. | ALA3608015 | B | Inhibition of bovine lung sGC using diethylamine NONOate as NO donor at 100 uM by [3H]-cGMP radioimmunoassay relative to control | Bos taurus | 6 | assay format | Scientific Literature | ||
| 3. | ALA3608016 | B | Inhibition of bovine lung sGC using GTP as substrate assessed as inhibition of NO-stimulated cGMP formation at 100 uM preincubated with protein followed by NO addition measured after 2 mins by radioimmunoassay relative to control | Bos taurus | 13 | assay format | Scientific Literature | ||
| 4. | ALA3608017 | B | Inhibition of bovine lung sGC using 1000 uM GTP as substrate assessed as inhibition of 0.3 nM NO-stimulated cGMP formation preincubated with protein followed by NO addition measured after 2 mins by radioimmunoassay | Bos taurus | 1 | assay format | Scientific Literature | ||
| 5. | ALA3608018 | B | Inhibition of bovine lung sGC using 200 uM GTP as substrate assessed as inhibition of 0.3 nM NO-stimulated cGMP formation preincubated with protein followed by NO addition measured after 2 mins by radioimmunoassay | Bos taurus | 1 | assay format | Scientific Literature | ||
| 6. | ALA3608019 | B | Inhibition of bovine lung sGC using 50 uM GTP as substrate assessed as inhibition of 0.3 nM NO-stimulated cGMP formation preincubated with protein followed by NO addition measured after 2 mins by radioimmunoassay | Bos taurus | 1 | assay format | Scientific Literature | ||
| 7. | ALA3608020 | B | Inhibition of bovine lung sGC using 1000 uM GTP as substrate assessed as inhibition of 10 nM NO-stimulated cGMP formation preincubated with protein followed by NO addition measured after 2 mins by radioimmunoassay | Bos taurus | 1 | assay format | Scientific Literature | ||
| 8. | ALA3608021 | B | Inhibition of bovine lung sGC using 200 uM GTP as substrate assessed as inhibition of 10 nM NO-stimulated cGMP formation preincubated with protein followed by NO addition measured after 2 mins by radioimmunoassay | Bos taurus | 1 | assay format | Scientific Literature | ||
| 9. | ALA3608022 | B | Inhibition of bovine lung sGC using 50 uM GTP as substrate assessed as inhibition of 10 nM NO-stimulated cGMP formation preincubated with protein followed by NO addition measured after 2 mins by radioimmunoassay | Bos taurus | 1 | assay format | Scientific Literature | ||
| 10. | ALA3608023 | B | Inhibition of sGC (unknown origin) assessed as inhibition of cGMP production in presence of 1 uM sGC activator cinaciguat | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 11. | ALA3608024 | B | Inhibition of sGC (unknown origin) assessed as inhibition of cGMP production in presence of 20 nM sGC activator cinaciguat | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 12. | ALA3608025 | B | Inhibition of rat lung membrane-bound particulate GC assessed as inhibition of 1 uM ANP-induced cGMP production after 10.5 to 12.5 mins by radioimmunoassay | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 13. | ALA3608026 | B | Inhibition of rat lung membrane-bound particulate GC assessed as inhibition of 10 nM ANP-induced cGMP production after 10.5 to 12.5 mins by radioimmunoassay | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 14. | ALA3608027 | B | Inhibition of rat lung membrane-bound particulate GC assessed as inhibition of cGMP production after 10.5 to 12.5 mins by radioimmunoassay | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 15. | ALA3608028 | B | Inhibition of sGC in rat cerebellar slices assessed as inhibition of NMDA-induced cGMP production at 100 uM preincubated for 10 mins followed by phosphodiesterase inhibitor IBMX addition by radioimmunoassay | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 16. | ALA3608029 | B | Inhibition of sGC in rat cerebellar slices assessed as inhibition of NMDA-induced cGMP production at 1 uM preincubated for 10 mins followed by phosphodiesterase inhibitor IBMX addition by radioimmunoassay | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 17. | ALA3608030 | B | Binding affinity to full length human recombinant sGC by surface plasmon resonance analysis | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 18. | ALA3608031 | B | Inhibition of adenylyl cyclase (unknown origin) | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 19. | ALA3608032 | B | Inhibition of forskolin-stimulated adenylyl cyclase (unknown origin) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4420560 | F | Cytotoxicity against human NCI-H1703 cells assessed as cell viability at 1 uM incubated for 48 hrs by MTT assay relative to control | Homo sapiens | 68 | cell-based format | Patent Bioactivity Data |
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