# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3607180 | B | Antagonist activity against human S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor translocation | Homo sapiens | 47 | cell-based format | Scientific Literature | ||
2. | ALA3607260 | A | Intrinsic clearance in human liver microsomes pre-incubated at 37 degC for 5 mins before NADPH addition by LCMS/MS method | Homo sapiens | 39 | assay format | Scientific Literature | ||
3. | ALA3607262 | B | Antagonist activity against mouse S1P1 receptor expressed in human U2OS cells co-expressing GFP assessed as inhibition of S1P-induced receptor translocation | Mus musculus | 2 | cell-based format | Scientific Literature | ||
4. | ALA3607265 | A | Oral bioavailability in Han Wistar rat at 5 to 10 mg/kg by LC-MS/MS method | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
5. | ALA3607270 | A | Clearance in Han Wistar rat at 2 to 4 mg/kg, iv by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
6. | ALA3607271 | A | Drug level in plasma of CB17 SCID mouse at 50 mg/kg, bid for 5 days measured 1 hr after first dose on day 1 and day 5 | Mus musculus | 2 | organism-based format | Scientific Literature | ||
7. | ALA3607272 | A | Induction of CYP1A2 activation in human hepatocytes at 0.2 to 20 uM incubated for 48 hrs using phenacetin substrate | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA3607273 | A | Induction of CYP2B6 activation in human hepatocytes at 0.2 to 20 uM incubated for 48 hrs using bupropion substrate | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA3607274 | A | Induction of CYP3A4 activation in human hepatocytes at 0.2 to 20 uM incubated for 48 hrs using testosterone substrate | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA3607275 | A | Induction of CYP3A5 activation in human hepatocytes at 0.2 to 20 uM incubated for 48 hrs using testosterone substrate | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA3607276 | A | Induction of CYP3A4 activation in human hepatocytes at 2 uM incubated for 48 hrs using testosterone substrate | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA3607277 | A | Induction of CYP3A5 activation in human hepatocytes at 2 uM incubated for 48 hrs using testosterone substrate | Homo sapiens | 2 | cell-based format | Scientific Literature |