# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3609987 | B | Inhibition of EGFR L858R/T790M double mutant in human H1975 cells assessed as inhibition of phosphorylation at Y1068 after 2 hrs by sandwich ELISA method | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
2. | ALA3609988 | B | Inhibition of EGFR E746-A750 deletion mutant in human PC9 cells assessed as inhibition of phosphorylation at Y1068 after 2 hrs by sandwich ELISA method | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
3. | ALA3609989 | B | Inhibition of EGFR L858R mutant in human H3255 cells assessed as inhibition of phosphorylation at Y1068 after 2 hrs by sandwich ELISA method | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
4. | ALA3609990 | B | Inhibition of EGFR deletion/T790M mutant in human PC9-DRH cells assessed as inhibition of phosphorylation at Y1068 after 2 hrs by sandwich ELISA method | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
5. | ALA3609991 | B | Inhibition of wild type EGFR in human A549 cells assessed as inhibition of phosphorylation at Y1068 after 2 hrs by sandwich ELISA method | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
6. | ALA4178350 | A | Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A549 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
7. | ALA4178351 | B | Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
8. | ALA4178352 | B | Selectivity index, ratio of IC50 for wild-type EGFR autophosphorylation in human A549 cells to IC50 for EGFR T790M/L858R double mutant autophosphorylation in human H1975 cells | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
9. | ALA4178353 | P | Lipophilicity, log D of the compound | 16 | small-molecule physicochemical format | Scientific Literature | |||
10. | ALA4178355 | P | Glutathione reactivity of the compound in pH 7.4 phosphate buffer assessed as half life at 1 uM up to 120 mins by LC-MS/MS analysis relative to canertinib | 15 | small-molecule physicochemical format | Scientific Literature | |||
11. | ALA4178356 | B | Inhibition of EGFR T790M/L858R double mutant (unknown origin) | Homo sapiens | 23 | single protein format | Scientific Literature | ||
12. | ALA4178358 | A | Intrinsic clearance in human liver microsomes at 1 uM up to 45 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 8 | microsome format | Scientific Literature | ||
13. | ALA4178360 | B | Inhibition of EGFR T790M/exon 19 deletion mutant phosphorylation in human PC9-DRH cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
14. | ALA4178361 | B | Inhibition of EGFR exon 19 deletion mutant phosphorylation in human PC9 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
15. | ALA4178362 | B | Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
16. | ALA4178363 | B | Selectivity index, ratio of IC50 for wild-type EGFR autophosphorylation in human A549 cells to IC50 for EGFR exon 19 deletion mutant autophosphorylation in human PC9 cells | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
17. | ALA4178437 | B | Inhibition of EGFR T790M/L858R double mutant (unknown origin) assessed as ratio of observed rate constant to inhibitor concentration at 0.05 uM | Homo sapiens | 1 | single protein format | Scientific Literature |