# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3611616 | Binding | Antagonist activity at Kv1.3 in human whole blood assessed as inhibition of thapsigargin-induced IL-2 secretion incubated for 30 prior to thapsigargin induction measured after 48 hrs by electrochemilluminescent immunoassay | Homo sapiens | 143 | ALA3608278 | single protein format | Scientific Literature | |
2. | ALA3611617 | Binding | Antagonist activity at Kv1.3 in human whole blood assessed as inhibition of thapsigargin-induced IFN-gamma secretion incubated for 30 prior to thapsigargin induction measured after 48 hrs by electrochemilluminescent immunoassay | Homo sapiens | 143 | ALA3608278 | single protein format | Scientific Literature | |
3. | ALA3611620 | Binding | Antagonist activity at human Kv1.3 expressed in CHOK1 cells assessed as inhibition of potassium currents by manual whole-cell patch clamp electrophysiology assay | Homo sapiens | 2 | ALA3608278 | cell-based format | Scientific Literature | |
4. | ALA3611621 | Binding | Antagonist activity at human Kv1.1 expressed in HEK293 cells assessed as inhibition of potassium currents by manual whole-cell patch clamp electrophysiology assay | Homo sapiens | 2 | ALA3608278 | cell-based format | Scientific Literature | |
5. | ALA3611623 | Binding | Selectivity ratio of IC50 for human Kv1.1 expressed in HEK293 cells by manual whole-cell patch clamp electrophysiology assay to IC50 for human Kv1.3 expressed in CHOK1 cells by manual whole-cell patch clamp electrophysiology assay | Homo sapiens | 1 | ALA3608278 | cell-based format | Scientific Literature | |
6. | ALA3611733 | Binding | Displacement of [125I]-ChTX from mouse Kv1.3 after 20 mins by scintillation counting analysis | Mus musculus | 1 | ALA3608278 | single protein format | Scientific Literature | |
7. | ALA3611734 | Binding | Selectivity for mouse Kv1.3 over mouse Kv1.1 | Mus musculus | 1 | ALA3608278 | assay format | Scientific Literature |