| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3611851 | B | Agonist activity at human LXRalpha expressed in African green monkey kidney CV1 cells co-expressing pTAL-LXRE including LXR response element incubated for 20 hrs by luciferase reporter gene assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 2. | ALA3611852 | B | Agonist activity at human LXRalpha expressed in African green monkey kidney CV1 cells co-expressing pTAL-LXRE including LXR response element incubated for 20 hrs by luciferase reporter gene assay relative to T0901317 | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 3. | ALA3610216 | B | Agonist activity at human LXRbeta expressed in African green monkey kidney CV1 cells co-expressing pTAL-LXRE including LXR response element incubated for 20 hrs by luciferase reporter gene assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 4. | ALA3610217 | B | Agonist activity at human LXRbeta expressed in African green monkey kidney CV1 cells co-expressing pTAL-LXRE including LXR response element incubated for 20 hrs by luciferase reporter gene assay relative to T0901317 | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 5. | ALA3610218 | F | Inhibition of cholesterol efflux in mouse RAW264.7 cells at 1 uM using [4-14C]-cholesterol incubated for 24 hrs by scintillation counting method relative to T0901317 | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA3610219 | F | Inhibition of cholesterol efflux in mouse RAW264.7 cells at 0.1 using [4-14C]-cholesterol incubated for 24 hrs by scintillation counting method relative to T0901317 | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA3610220 | A | Cmax in mouse at 10 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 8. | ALA3610221 | A | Plasma concentration in mouse at 10 mg/kg, po measured at 6 hrs | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA3610222 | F | Increase in ABCA1 mRNA expression in C57Bl/6 mouse blood at 1 mg/kg, po dosed daily for 7 days | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 10. | ALA3610223 | F | Effect on FAS mRNA expression in C57Bl/6 mouse liver at 1 mg/kg, po dosed daily for 7 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA3610224 | F | Effect on SCD1 mRNA expression in C57Bl/6 mouse liver at 1 mg/kg, po dosed daily for 7 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA3610225 | T | Toxicity in C57Bl/6 mouse assessed as effect on plasma triglyceride levels at 1 mg/kg, po dosed daily for 7 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA3610226 | F | Increase in ABCA1 mRNA expression in cynomolgus monkey blood at 0.1 to 10 mg/kg, po dosed daily for 14 days measured on day 1 | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA3610227 | F | Increase in ABCA1 mRNA expression in cynomolgus monkey blood at 0.1 to 10 mg/kg, po dosed daily for 14 days measured on day 14 | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3610228 | T | Toxicity in cynomolgus monkey assessed as effect on plasma triglyceride levels at 0.1 to 10 mg/kg, po dosed daily for 14 days | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3610229 | T | Toxicity in cynomolgus monkey assessed as effect on plasma triglyceride levels at 0.1 to 10 mg/kg, po administered as single dose | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3610230 | B | Agonist activity at His-LXRalpha/FLAG-RXRalpha (unknown origin) assessed as recruitment of PGC1alpha peptide (130 to 154 residues) pre-incubated for 60 mins before PGC1alpha addition followed by one night of incubation by FRET assay | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 18. | ALA3610231 | B | Agonist activity at His-LXRalpha/FLAG-RXRalpha (unknown origin) assessed as recruitment of ASC2 peptide (1481 to 1510 residues) pre-incubated for 60 mins before ASC2 peptide addition followed by one night of incubation by FRET assay | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 19. | ALA3610232 | B | Agonist activity at His-LXRbeta/FLAG-RXRalpha (unknown origin) assessed as recruitment of PGC1alpha peptide (130 to 154 residues) pre-incubated for 60 mins before PGC1alpha addition followed by one night of incubation by FRET assay | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 20. | ALA3610233 | B | Agonist activity at His-LXRbeta/FLAG-RXRalpha (unknown origin) assessed as recruitment of ASC2 peptide (1481 to 1510 residues) pre-incubated for 60 mins before ASC2 peptide addition followed by one night of incubation by FRET assay | Homo sapiens | 2 | protein complex format | Scientific Literature |
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