| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3611867 | A | Drug uptake in brain of APP YAC Tg mouse model at 30 mg/kg after 6 hrs | Mus musculus | 1 | ALA3608233 | organism-based format | Scientific Literature | |
| 2. | ALA3611868 | F | Reduction of amyloid beta 42 level in brain of APP YAC Tg mouse model at 30 mg/kg after 6 hrs relative to control | Mus musculus | 1 | ALA3608233 | organism-based format | Scientific Literature | |
| 3. | ALA3611869 | B | Modulation of gamma-secretase in human SH-SY5Y cells overexpressing APP C-terminal fragment SPA4CT assessed as inhibition of intracellular amyloid beta 40 production by electrochemiluminescent assay | Homo sapiens | 28 | ALA3608233 | cell-based format | Scientific Literature | |
| 4. | ALA3611870 | B | Modulation of gamma-secretase in human SH-SY5Y cells overexpressing APP C-terminal fragment SPA4CT assessed as inhibition of intracellular amyloid beta 42 production by electrochemiluminescent assay | Homo sapiens | 28 | ALA3608233 | cell-based format | Scientific Literature | |
| 5. | ALA3611871 | A | Plasma concentration in APP YAC Tg mouse model at 30 mg/kg after 6 hrs | Mus musculus | 1 | ALA3608233 | organism-based format | Scientific Literature | |
| 6. | ALA3611881 | B | Inhibition of gamma-secretase-mediated notch processing in human HeLa cells assessed as NICD level by split-luciferase reporter assay | Homo sapiens | 7 | ALA3608233 | cell-based format | Scientific Literature | |
| 7. | ALA3611882 | B | Binding affinity to human ERG expressed in HEK293 cells by radioligand displacement assay | Homo sapiens | 8 | ALA3608233 | cell-based format | Scientific Literature | |
| 8. | ALA3611883 | B | Inhibition of human ERG expressed in CHO cells by patch clamp assay | Homo sapiens | 8 | ALA3608233 | cell-based format | Scientific Literature | |
| 9. | ALA3611884 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM relative to control | Homo sapiens | 7 | ALA3608233 | single protein format | Scientific Literature | |
| 10. | ALA3611885 | A | Inhibition of CYP2C9 (unknown origin) at 1 uM relative to control | Homo sapiens | 7 | ALA3608233 | single protein format | Scientific Literature | |
| 11. | ALA3611886 | P | Solubility of the compound at pH 7 | 7 | ALA3608233 | small-molecule physicochemical format | Scientific Literature | ||
| 12. | ALA3611887 | P | Solubility of the compound at pH 2 | 6 | ALA3608233 | small-molecule physicochemical format | Scientific Literature | ||
| 13. | ALA3611888 | A | Apparent permeability across pig LLC-PK1 cells | Sus scrofa | 5 | ALA3608233 | cell-based format | Scientific Literature | |
| 14. | ALA3611889 | A | Substrate activity at P-gp in rat assessed as efflux ratio of permeability from basolateral to apical over apical to basolateral side | Rattus norvegicus | 5 | ALA3608233 | assay format | Scientific Literature | |
| 15. | ALA3611890 | A | Substrate activity at P-gp in human assessed as efflux ratio of permeability from basolateral to apical over apical to basolateral side | Homo sapiens | 5 | ALA3608233 | assay format | Scientific Literature | |
| 16. | ALA3611891 | A | Intrinsic clearance in rat hepatocytes | Rattus norvegicus | 7 | ALA3608233 | cell-based format | Scientific Literature | |
| 17. | ALA3611892 | A | Intrinsic clearance in dog hepatocytes | Canis lupus familiaris | 7 | ALA3608233 | cell-based format | Scientific Literature | |
| 18. | ALA3611893 | A | Intrinsic clearance in human hepatocytes | Homo sapiens | 7 | ALA3608233 | cell-based format | Scientific Literature | |
| 19. | ALA3609918 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv and 2 mg/kg, po | Rattus norvegicus | 7 | ALA3608233 | organism-based format | Scientific Literature | |
| 20. | ALA3609919 | A | Volume of distribution in Sprague-Dawley rat at 1 mg/kg, iv and 2 mg/kg, po | Rattus norvegicus | 7 | ALA3608233 | organism-based format | Scientific Literature |
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