# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3615818 | Binding | Displacement of [3H]raclopride from dopamine D2 receptor in Sprague-Dawley rat striatal membranes after 30 mins | Rattus norvegicus | 11 | ALA3611999 | assay format | Scientific Literature | |
2. | ALA3615819 | Binding | Displacement of [3H]epibatidine from immunoimmobilized alpha4beta2 nAChR in Sprague-Dawley rat striatal membranes by liquid scintillation counting | Rattus norvegicus | 11 | ALA3611999 | assay format | Scientific Literature | |
3. | ALA3615820 | Binding | Displacement of [3H]epibatidine from immunoimmobilized alpha6beta2 nAChR in Sprague-Dawley rat striatal membranes by liquid scintillation counting | Rattus norvegicus | 11 | ALA3611999 | assay format | Scientific Literature | |
4. | ALA3615821 | Binding | Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in Sprague-Dawley rat hippocampus membrane homogenates by gamma counting | Rattus norvegicus | 11 | ALA3611999 | assay format | Scientific Literature | |
5. | ALA3615823 | Binding | Ratio of NHNB Ki to compound Ki for immunoimmobilized alpha4beta2 nAChR in Sprague-Dawley rat striatal membranes | Rattus norvegicus | 3 | ALA3611999 | assay format | Scientific Literature | |
6. | ALA3615824 | Binding | Ratio of NHNB Ki to compound Ki for immunoimmobilized alpha6beta2 nAChR in Sprague-Dawley rat striatal membranes | Rattus norvegicus | 3 | ALA3611999 | assay format | Scientific Literature | |
7. | ALA3615825 | Binding | Displacement of [3H]raclopride from dopamine D3 receptor (unknown origin) expressed in HEK293 cells after 30 mins | Homo sapiens | 4 | ALA3611999 | cell-based format | Scientific Literature | |
8. | ALA3615826 | Binding | Antagonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as inhibition of acetylcholine-induced inward current at holding potential of -70 mV by patch clamp technique | Homo sapiens | 8 | ALA3611999 | cell-based format | Scientific Literature | |
9. | ALA3615923 | Binding | Partial agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as inward current at holding potential of -70 mV by patch clamp technique relative to acetylcholine | Homo sapiens | 8 | ALA3611999 | cell-based format | Scientific Literature | |
10. | ALA3615924 | Binding | Agonist activity at nAChR in Sprague-Dawley rat striatal slices assessed as induction of [3H]-dopamine release | Rattus norvegicus | 4 | ALA3611999 | assay format | Scientific Literature | |
11. | ALA3615925 | Binding | Antagonist activity at nAChR in Sprague-Dawley rat striatal slices assessed as inhibition of nicotine-induced [3H]-dopamine release | Rattus norvegicus | 10 | ALA3611999 | assay format | Scientific Literature | |
12. | ALA3615930 | Binding | Induction of ERK1/2 phosphorylation in human HEK293 cells at 10 uM after 5 mins by Western blotting | Homo sapiens | 4 | ALA3611999 | cell-based format | Scientific Literature | |
13. | ALA3615931 | Binding | Agonist activity at dopamine D2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of ERK1/2 phosphorylation at 10 uM after 5 mins by Western blotting | Homo sapiens | 6 | ALA3611999 | cell-based format | Scientific Literature | |
14. | ALA3615933 | Binding | Agonist activity at alpha4beta2 nAChR (unknown origin) expressed in HEK293 cells assessed as increase of ERK1/2 phosphorylation at 10 uM after 5 mins by Western blotting | Homo sapiens | 5 | ALA3611999 | cell-based format | Scientific Literature | |
15. | ALA3615934 | Binding | Antagonist activity at alpha4beta2 nAChR (unknown origin) expressed in HEK293 cells assessed as reduction of nicotine-induced ERK1/2 phosphorylation at 10 uM treated 30 mins before nicotine addition by Western blotting | Homo sapiens | 4 | ALA3611999 | cell-based format | Scientific Literature |