| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3614714 | B | Inhibition of FTO R96Q (unknown origin) expressed in mouse 3T3L1 cells increase in demethylation of m6A modified mRNA levels at 10 uM incubated for 48 hrs by dot blot method | Homo sapiens | 1 | ALA3612002 | cell-based format | Scientific Literature | |
| 2. | ALA3614715 | B | Inhibition of FTO (unknown origin) (31 to 505 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in 3-meT substrate demethylation by measuring demethylation ratio at 80 uM incubated for 17 hrs at 16 degC by HPLC method | Homo sapiens | 20 | ALA3612002 | cell-based format | Scientific Literature | |
| 3. | ALA3614716 | B | Inhibition of FTO (unknown origin) (31 to 505 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in 15-mer ssRNA (5'-CUUGUCA(m6A)CAGCAGA-3') substrate demethylation by measuring demethylation ratio at 80 uM incubated for 0.5 hrs at room temperature by LC/MS method | Homo sapiens | 1 | ALA3612002 | cell-based format | Scientific Literature | |
| 4. | ALA3614717 | B | Binding affinity to FTO (unknown origin) (31 to 505 residues) expressed in Escherichia coli BL21 (DE3) by ITC method | Homo sapiens | 1 | ALA3612002 | assay format | Scientific Literature | |
| 5. | ALA3614718 | A | Cytotoxicity against mouse 3T3L1 cells assessed as effect on cell morphology at 1 to 20 uM incubated for 8 days | Mus musculus | 1 | ALA3612002 | cell-based format | Scientific Literature | |
| 6. | ALA3614719 | B | Inhibition of FTO (unknown origin) expressed in mouse 3T3L1 cells increase in demethylation of m6A modified mRNA levels at 10 uM incubated for 48 hrs by dot blot method | Homo sapiens | 1 | ALA3612002 | cell-based format | Scientific Literature | |
| 7. | ALA3614720 | B | Inhibition of FTO in mouse 3T3L1 cells increase in demethylation of m6A modified mRNA levels at 10 uM incubated for 48 hrs by dot blot method | Mus musculus | 1 | ALA3612002 | cell-based format | Scientific Literature | |
| 8. | ALA5245691 | B | Inhibition of FTO (unknown origin) (31 to 505 residues) mediated demethylation activity expressed in Escherichia coli BL21(DE3) using 15-mer ssRNA oligonucleotide (5'-CUUGUCA(m6A)CAGCAGA-3') as substrate incubated for 0.5 hrs by LC-MS/MS analysis | Homo sapiens | 2 | ALA5244237 | assay format | Scientific Literature |
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