| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3620322 | B | Inhibition of ERCC1-XPF (unknown origin) by high-throughput fluorescence based in-vitro endonuclease assay | Homo sapiens | 43 | protein complex format | Scientific Literature | ||
| 2. | ALA3620428 | B | Inhibition of FEN1 (unknown origin) | Homo sapiens | 41 | single protein format | Scientific Literature | ||
| 3. | ALA3620429 | B | Inhibition of DNAse1 (unknown origin) | Homo sapiens | 41 | single protein format | Scientific Literature | ||
| 4. | ALA3620430 | P | Lipophilicity, log D of the compound | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA3620431 | A | Cytotoxicity against human HepG2 cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA3620432 | A | Half life in mouse liver microsomes | Mus musculus | 2 | assay format | Scientific Literature | ||
| 7. | ALA3620433 | A | Half life in human liver microsomes | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 8. | ALA3620434 | P | Apparent permeability by PAMPA method | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA3620435 | B | Binding affinity to ERCC1-XPF (unknown origin) by SPR assay | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 10. | ALA3620436 | B | Inhibition of ERCC1-XPF in human A375 cells assessed as reduction in direct nucleotide excision repair of UV-damaged pEGFP plasmid incubated for 234 hrs by recombinant GFP reporter assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA3620437 | A | Cytotoxicity against human A375 cells assessed as reduction in cell number at 4.89 uM incubated for 5 days | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA3620438 | A | Cytotoxicity against human A375 cells assessed as reduction in cell number at 10 uM incubated for 5 days | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA3620439 | B | Inhibition of ERCC1-XPF in human A375 cells assessed as potentiation of cisplatin-induced cytotoxicity at 0.624 uM incubated for 5 days | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA3620440 | B | Inhibition of ERCC1-XPF in human A375 cells assessed as potentiation of cisplatin-induced cytotoxicity at 1.28 uM incubated for 5 days | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA3620441 | B | Inhibition of ERCC1-XPF in human A375 cells assessed as potentiation of cisplatin-induced cytotoxicity at 2.48 uM incubated for 5 days | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA3620442 | B | Inhibition of ERCC1-XPF in human A375 cells assessed as potentiation of cisplatin-induced cytotoxicity at 4.96 uM incubated for 5 days | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA3620443 | B | Inhibition of ERCC1-XPF in human A375 cells assessed as potentiation of cisplatin-induced cytotoxicity at 10 uM incubated for 5 days | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA3620444 | B | Inhibition of ERCC1-XPF in human A375 cells assessed as induction of delay in DNA repair by measuring cumulative frequency of cells at 10 uM pre-incubated for 1 hr before 5 uM cisplatin exposure for 1 hr and measured after 6 hrs by immunohistochemistry based gammaH2AX foci assay (Rvb = 45.43%) | Homo sapiens | 1 | cell-based format | Scientific Literature |
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