| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3624350 | B | Inhibition of human CYP11B2 expressed in V79 cells assessed as aldosterone level after 3 hrs by HTRF assay in presence of 125 nM 11-deoxycorticosterone | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 2. | ALA3624351 | B | Inhibition of human CYP11B1 expressed in V79 cells assessed as cortisol level after 3 hrs by HTRF assay in presence of 250 nM 11-deoxycortisol | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 3. | ALA3625231 | B | Selectivity index, ratio IC50 for human CYP11B1 to IC50 for human CYP11B2 | Homo sapiens | 12 | assay format | Scientific Literature | ||
| 4. | ALA3625232 | P | Lipophilicity, log D of the compound by HPLC | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA3625233 | A | Intrinsic clearance in Sprague-Dawley rat liver microsomes by LC/MS method | Rattus norvegicus | 6 | assay format | Scientific Literature | ||
| 6. | ALA3625347 | A | Oral bioavailability in Sprague-Dawley rat at 2 mg/kg administered through gavage | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 7. | ALA3625348 | A | Dose normalized AUC in Sprague-Dawley rat at 2 mg/kg, po administered through gavage | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 8. | ALA3625349 | A | Plasma clearance in Sprague-Dawley rat at 2 mg/kg, po administered through gavage by LC/MS/MS method | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 9. | ALA3625350 | A | Half life in Sprague-Dawley rat at 2 mg/kg, po administered through gavage by LC/MS/MS method | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 10. | ALA3625351 | B | Inhibition of human CYP17 expressed in COS7 cells assessed as DHEA level after 3 hrs by EIA assay in presence of 360 nM 17-hydroxypregnenolone | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA3625352 | B | Inhibition of human CYP19 | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 12. | ALA3625353 | A | Inhibition of human CYP3A4 | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 13. | ALA3625354 | A | Plasma protein binding in Sprague-Dawley rat | Rattus norvegicus | 3 | cell-free format | Scientific Literature | ||
| 14. | ALA3625355 | A | Plasma protein binding in rhesus monkey | Macaca mulatta | 1 | cell-free format | Scientific Literature | ||
| 15. | ALA3625356 | A | Intrinsic clearance in rhesus monkey liver microsomes by LC/MS method | Macaca mulatta | 1 | assay format | Scientific Literature | ||
| 16. | ALA3625357 | A | Oral bioavailability in rhesus monkey at 2 mg/kg administered through gavage | Macaca mulatta | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3625358 | A | Dose normalized AUC in rhesus monkey at 2 mg/kg administered through gavage | Macaca mulatta | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3625359 | A | Plasma clearance in rhesus monkey at 2 mg/kg administered through gavage by LC-MS/MS method | Macaca mulatta | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3625360 | A | Half life in rhesus monkey at 2 mg/kg administered through gavage | Macaca mulatta | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3625364 | B | Inhibition of rhesus monkey CYP11B2 expressed in V79 cells assessed as aldosterone level after 3 hrs by HTRF assay in presence of 125 nM 11-deoxycorticosterone | Macaca mulatta | 3 | cell-based format | Scientific Literature |
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