# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3625951 | B | Inhibition of SIRT6 in human BxPC-3 cells assessed as increase in H3K9 acetylation by immunoblotting assay relative to control | Homo sapiens | 4 | ALA3621196 | cell-based format | Scientific Literature | |
2. | ALA3625952 | A | Cytotoxicity against human BxPC3 cells assessed as cell viability at 30 uM after 72 hrs by CellTiter96 Aqueous1 assay | Homo sapiens | 3 | ALA3621196 | cell-based format | Scientific Literature | |
3. | ALA3625953 | B | Inhibition of human SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay | Homo sapiens | 14 | ALA3621196 | single protein format | Scientific Literature | |
4. | ALA3625954 | B | Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assay | Homo sapiens | 14 | ALA3621196 | single protein format | Scientific Literature | |
5. | ALA3625955 | B | Inhibition of human SIRT1 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay | Homo sapiens | 4 | ALA3621196 | single protein format | Scientific Literature | |
6. | ALA3625956 | B | Inhibition of human SIRT2 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay | Homo sapiens | 4 | ALA3621196 | single protein format | Scientific Literature | |
7. | ALA3625957 | B | Selectivity ratio of IC50 for human SIRT1 to IC50 for human SIRT6 | Homo sapiens | 4 | ALA3621196 | assay format | Scientific Literature | |
8. | ALA3625958 | B | Selectivity ratio of IC50 for human SIRT2 to IC50 for human SIRT6 | Homo sapiens | 4 | ALA3621196 | assay format | Scientific Literature | |
9. | ALA3625961 | B | Inhibition of SIRT6 in human BxPC-3 cells assessed as increase in radiolabelled glucose uptake at 100 uM after 18 hrs by fluorescence plate reader relative to control | Homo sapiens | 4 | ALA3621196 | cell-based format | Scientific Literature | |
10. | ALA3625962 | B | Inhibition of SIRT6 in rat L6 cells assessed as increase in radiolabelled glucose uptake at 100 uM after 18 hrs by fluorescence plate reader relative to control | Rattus norvegicus | 4 | ALA3621196 | cell-based format | Scientific Literature | |
11. | ALA3625963 | B | Inhibition of SIRT6 in rat L6 cells assessed as increase in 2-NBDG uptake at 100 uM after 18 hrs by fluorescence plate reader relative to control | Rattus norvegicus | 4 | ALA3621196 | cell-based format | Scientific Literature | |
12. | ALA3625965 | B | Inhibition of SIRT6 in human PBMC assessed as inhibition of PHA-induced TNF alpha production at 100 uM after 3 days by ELISA | Homo sapiens | 3 | ALA3621196 | single protein format | Scientific Literature | |
13. | ALA3625967 | B | Inhibition of SIRT6 in human PBMC assessed as inhibition of MLR-induced TNF alpha production at 100 uM after 3 days by ELISA | Homo sapiens | 3 | ALA3621196 | single protein format | Scientific Literature | |
14. | ALA3626082 | A | Cytotoxicity against PHA-induced human PBMC assessed as cell viability using propidium iodide by flow cytometry | Homo sapiens | 3 | ALA3621196 | cell-based format | Scientific Literature | |
15. | ALA3626083 | A | Cytotoxicity against MLR-induced human PBMC assessed as cell viability using propidium iodide by flow cytometry | Homo sapiens | 3 | ALA3621196 | cell-based format | Scientific Literature | |
16. | ALA3626084 | A | Cytotoxicity against human HEK293 cells assessed as cell viability using propidium iodide by flow cytometry | Homo sapiens | 3 | ALA3621196 | cell-based format | Scientific Literature | |
17. | ALA3626092 | B | Inhibition of SIRT6 in human BxPC3 cells assessed as potentiation of gemcitabine-induced cytotoxicity by measuring cell viability at 30 uM by CellTiter96 Aqueous1 assay | Homo sapiens | 2 | ALA3621196 | cell-based format | Scientific Literature | |
18. | ALA3626093 | B | Inhibition of SIRT6 in human BxPC3 cells assessed as reduction in TNF alpha production by ELISA | Homo sapiens | 4 | ALA3621196 | cell-based format | Scientific Literature | |
19. | ALA3626094 | B | Inhibition of human SIRT6 in BRCA2-dependent Capan1 cells assessed as potentiation of NU1025-induced cytotoxicity by measuring cell viability at 100 uM after 7 days by CellTiter96 Aqueous1 assay | Homo sapiens | 3 | ALA3621196 | cell-based format | Scientific Literature |