| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3625861 | B | Inhibition of muscarinic receptor (unknown origin) | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 2. | ALA3625862 | B | Inhibition of dopamine receptor (unknown origin) | Homo sapiens | 4 | protein format | Scientific Literature | ||
| 3. | ALA3625863 | B | Inhibition of serotonin receptor (unknown origin) | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 4. | ALA3625864 | B | Inhibition of histamine receptor (unknown origin) | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 5. | ALA3625869 | F | Antitrypanosomal activity against Trypanosoma brucei brucei BSF427 VSG118 bloodstream forms incubated for 69 hrs by resazurin dye based assay | Trypanosoma brucei brucei | 53 | organism-based format | Scientific Literature | ||
| 6. | ALA3625870 | A | Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 69 hrs by resazurin dye based assay | Homo sapiens | 53 | cell-based format | Scientific Literature | ||
| 7. | ALA3625871 | A | Intrinsic clearance in CD1 mouse liver microsomes incubated for 3 to 30 mins in presence of NADPH by UPLC/MS/MS method | Mus musculus | 45 | assay format | Scientific Literature | ||
| 8. | ALA3625872 | A | Intrinsic clearance in Sprague-Dawley rat liver microsomes incubated for 3 to 30 mins in presence of NADPH by UPLC/MS/MS method | Rattus norvegicus | 27 | assay format | Scientific Literature | ||
| 9. | ALA3625873 | A | Intrinsic clearance in pooled mixed gender human liver microsomes incubated for 3 to 30 mins in presence of NADPH by UPLC/MS/MS method | Homo sapiens | 29 | assay format | Scientific Literature | ||
| 10. | ALA3625874 | T | Selectivity index, ratio of EC50 for cytotoxicty against human MRC5 cells to EC50 for antitrypanosomal activity against Trypanosoma brucei brucei BSF427 VSG118 bloodstream forms | 5 | cell-based format | Scientific Literature | |||
| 11. | ALA3625875 | P | Solubility of the compound | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA3625876 | A | Fraction unbound in mouse plasma | Mus musculus | 4 | cell-free format | Scientific Literature | ||
| 13. | ALA3625878 | A | Fraction unbound in NMRI mouse brain at 0.5 to 1 free base/kg, iv by UPLC/MS/MS method | Mus musculus | 5 | organism-based format | Scientific Literature | ||
| 14. | ALA3625879 | F | Antitrypanosomal activity against Trypanosoma brucei brucei S427 infected in HRN mouse model of stage-1 human African trypanosomiasis assessed as reduction in parasitemia at 3 mg/kg, ip bid for 4 days starting 3 days post infection | Trypanosoma brucei brucei | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3625880 | F | Antitrypanosomal activity against Trypanosoma brucei brucei S427 infected in HRN mouse model of stage-1 human African trypanosomiasis assessed as reduction in infection relapse at 3 mg/kg, ip bid for 4 days starting 3 days post infection and measured up to 30 days post infection | Trypanosoma brucei brucei | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3625881 | F | Antitrypanosomal activity against Trypanosoma brucei brucei S427 infected in NMRI mouse model of stage-1 human African trypanosomiasis assessed as reduction in infection cure at 10 mg/kg, ip bid for 4 days starting 3 days post infection | Trypanosoma brucei brucei | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3625882 | F | Antitrypanosomal activity against Trypanosoma brucei brucei S427 infected in NMRI mouse model of stage-1 human African trypanosomiasis assessed as reduction in infection relapse at 10 mg/kg, ip bid for 4 days starting 3 days post infection and measured up to 30 days post infection | Trypanosoma brucei brucei | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3625883 | U | Time duration during which blood free concentration above EC99 for antitrypanosomal activity against Trypanosoma brucei brucei S427 infected in NMRI mouse model of stage-1 human African trypanosomiasis at 10 mg/kg, ip bid for 4 days starting 3 days post infection | Trypanosoma brucei brucei | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3625884 | F | Trypanocidal activity against Trypanosoma brucei brucei at 0.6 uM incubated for 24 hrs by resazurin dye based static-cidal assay | Trypanosoma brucei brucei | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3625885 | A | Cmax in HRN mouse at 10 mg free base/kg, ip by UPLC/MS/MS method | Mus musculus | 1 | organism-based format | Scientific Literature |
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