# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3625462 | F | Anticancer activity against human HuH7 cells assessed as inhibition of cell growth at 10 uM incubated for 4 days by CCK8 assay | Homo sapiens | 17 | ALA3621060 | cell-based format | Scientific Literature | |
2. | ALA3625463 | F | Anticancer activity against human A549 cells assessed as inhibition of cell growth at 10 uM incubated for 4 days by CCK8 assay | Homo sapiens | 17 | ALA3621060 | cell-based format | Scientific Literature | |
3. | ALA5137290 | F | Antiplatelet activity against ADP-induced human platelet in platelet rich plasma assessed as inhibition of platelet aggregation at 10 uM preincubated for 2 mins followed by ADP stimulation and measured for 5 mins by aggregometry relative to control | Homo sapiens | 42 | ALA5136966 | cell-based format | Scientific Literature | |
4. | ALA5137291 | F | Antiplatelet activity against ADP-induced human platelet in platelet rich plasma assessed as inhibition of platelet aggregation at 3 uM preincubated for 2 mins followed by ADP stimulation and measured for 5 mins by aggregometry relative to control | Homo sapiens | 22 | ALA5136966 | cell-based format | Scientific Literature | |
5. | ALA5137292 | F | Antiplatelet activity against ADP-induced human platelet in platelet rich plasma assessed as inhibition of platelet aggregation preincubated for 2 mins followed by ADP stimulation and measured for 5 mins by aggregometry | Homo sapiens | 13 | ALA5136966 | cell-based format | Scientific Literature | |
6. | ALA5137293 | F | Potency index, ratio of ticagrelor IC50 to test compound IC50 for antiplatelet activity against ADP-induced human platelet in platelet rich plasma assessed as inhibition of platelet aggregation | Homo sapiens | 2 | ALA5136966 | cell-based format | Scientific Literature | |
7. | ALA5137294 | F | Antiplatelet activity against ADP-induced platelet aggregation in mouse assessed as inhibition of platelet aggregation at 2.5 mg/kg, iv measured after 1 hr by turbidimetric method relative to control | Mus musculus | 2 | ALA5136966 | organism-based format | Scientific Literature | |
8. | ALA5137295 | F | Antiplatelet activity against ADP-induced platelet aggregation in mouse assessed as inhibition of platelet aggregation at 5 mg/kg, po measured after 1 hr by turbidimetric method relative to control | Mus musculus | 2 | ALA5136966 | organism-based format | Scientific Literature | |
9. | ALA5137296 | T | Toxicity in mouse assessed as bleeding time at 5 mg/kg, po administered via gavage measured after 1 hr by bleeding tail test (Rvb = 5.2 mins) | Mus musculus | 2 | ALA5136966 | organism-based format | Scientific Literature | |
10. | ALA5137297 | T | Toxicity in mouse assessed as blood loss at 5 mg/kg, po administered via gavage measured after 1 hr by bleeding tail test (Rvb = 34.92 uL) | Mus musculus | 2 | ALA5136966 | organism-based format | Scientific Literature | |
11. | ALA5137298 | T | Toxicity in mouse assessed as death at 1500 mg/kg, po administered via gavage measured for 14 days | Mus musculus | 1 | ALA5136966 | organism-based format | Scientific Literature | |
12. | ALA5137299 | T | Toxicity in mouse assessed as change in body weight at 1500 mg/kg, po administered via gavage measured for 14 days | Mus musculus | 1 | ALA5136966 | organism-based format | Scientific Literature | |
13. | ALA5137300 | P | Stability of compound in PBS buffer incubated for 1 week at 37 degC | 1 | ALA5136966 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA5137301 | A | Stability of compound in fasted-state simulated gastric fluid incubated for 1 day | 1 | ALA5136966 | assay format | Scientific Literature | ||
15. | ALA5137302 | A | Stability of compound in fasted-state simulated intestinal fluid incubated for 1 day | 1 | ALA5136966 | assay format | Scientific Literature | ||
16. | ALA5137303 | A | Stability in mouse liver microsomes measured after 1 hr | Mus musculus | 1 | ALA5136966 | microsome format | Scientific Literature | |
17. | ALA5137304 | A | Stability in mouse liver microsomes measured after 2 hrs | Mus musculus | 1 | ALA5136966 | microsome format | Scientific Literature | |
18. | ALA5137305 | F | Inhibition of P2Y12 receptor in human platelet assessed as reduction in ADP-induced VASP phosphorylation by flow cytometry | Homo sapiens | 2 | ALA5136966 | cell-based format | Scientific Literature |