Antitumor activity against human Caki1 cells xenografted in BALB/c nu mouse assessed as tumor growth inhibition at 1 mg/kg, po administered 5 times a week for 4 weeks measured after 42 days relative to control
Antitumor activity against human Caki1 cells xenografted in BALB/c nu mouse assessed as tumor growth inhibition at 3 mg/kg, po administered 5 times a week for 4 weeks measured after 42 days relative to control
Toxicity in human Caki1 cells xenografted BALB/c nu mouse assessed as body weight change at 1 mg/kg, po administered 5 times a week for 4 weeks measured every 2 to 3 days
Toxicity in human Caki1 cells xenografted BALB/c nu mouse assessed as body weight change at 3 mg/kg, po administered 5 times a week for 4 weeks measured every 2 to 3 days
Antitumor activity against human Caki1 cells xenografted BALB/c-nu mouse assessed as down regulation of PCNA in tumor tissue at 1 to 3 mg/kg, po administered 5 times a week for 4 weeks by Western blot analysis
Antitumor activity against human Caki1 cells xenografted BALB/c-nu mouse assessed as down regulation of NNMT in tumor tissue at 1 to 3 mg/kg, po administered 5 times a week for 4 weeks by Western blot analysis
Antitumor activity against human Caki1 cells xenografted BALB/c-nu mouse assessed as up-regulation of phosphorylated JNK in tumor tissue at 1 to 3 mg/kg, po administered 5 times a week for 4 weeks by Western blot analysis
Antitumor activity against human Caki1 cells xenografted BALB/c-nu mouse assessed as down-regulation of phosphorylated p38 in tumor tissue at 1 to 3 mg/kg, po administered 5 times a week for 4 weeks by Western blot analysis