# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3626114 | B | Inhibition of human CYP11B2 expressed in human renal leiomyoblastoma cells using 11-deoxycorticosterone as substrate assessed as formation of aldosterone after 16 hrs by HTRF assay | Homo sapiens | 11 | ALA3621059 | cell-based format | Scientific Literature | |
2. | ALA3626115 | B | Selectivity factor, ratio of IC50 for human CYP11B1 to IC50 for human CYP11B2 | Homo sapiens | 13 | ALA3621059 | assay format | Scientific Literature | |
3. | ALA3626116 | A | Clearance in human microsomes assessed per mg of protein | Homo sapiens | 11 | ALA3621059 | assay format | Scientific Literature | |
4. | ALA3626117 | A | Clearance in mouse microsomes assessed per mg of protein | Mus musculus | 11 | ALA3621059 | assay format | Scientific Literature | |
5. | ALA3626118 | A | Clearance in rat microsomes assessed per mg of protein | Rattus norvegicus | 11 | ALA3621059 | assay format | Scientific Literature | |
6. | ALA3626119 | B | Inhibition of cynomolgus monkey CYP11B2 expressed in human renal leiomyoblastoma cells using 11-deoxycorticosterone as substrate assessed as formation of aldosterone after 16 hrs by HTRF assay | Macaca fascicularis | 1 | ALA3621059 | cell-based format | Scientific Literature | |
7. | ALA3626120 | B | Selectivity factor, ratio of IC50 for cynomolgus monkey CYP11B1 to IC50 for cynomolgus monkey CYP11B2 | Macaca fascicularis | 1 | ALA3621059 | assay format | Scientific Literature | |
8. | ALA3626121 | B | Inhibition of mouse CYP11B2 expressed in human renal leiomyoblastoma cells using 11-deoxycorticosterone as substrate assessed as formation of aldosterone after 16 hrs by HTRF assay | Mus musculus | 2 | ALA3621059 | cell-based format | Scientific Literature | |
9. | ALA3626122 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 9 | ALA3621059 | single protein format | Scientific Literature | |
10. | ALA3626123 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 9 | ALA3621059 | single protein format | Scientific Literature | |
11. | ALA3626124 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 9 | ALA3621059 | single protein format | Scientific Literature | |
12. | ALA3626125 | P | 1-octanol/TAPSO buffer partition coefficient, log D of the compound at pH 7.4 by spectrophotometric analysis | 8 | ALA3621059 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA3626126 | P | Aqueous solubility of the compound in phosphate buffer at pH 6.5 by LYSA method | 8 | ALA3621059 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA3624658 | P | Permeability of the compound by PAMPA | 8 | ALA3621059 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA3624659 | F | Reduction of plasma aldosterone level in obese diabetic db/db mouse administered through food admix treatment for 21 days by LC-MS/MS analysis | Mus musculus | 1 | ALA3621059 | organism-based format | Scientific Literature | |
16. | ALA3624661 | F | Increase in plasma 11-deoxycorticosterone level in obese diabetic db/db mouse at 6 to 20 mg/kg administered through food admix treatment for 21 days by LC-MS/MS analysis | Mus musculus | 1 | ALA3621059 | organism-based format | Scientific Literature | |
17. | ALA3624667 | F | Reduction of aldosterone level in angiotension-2 ZSF1 rat infusion model at 20 mg/kg administered through food admix treatment for 6 weeks | Rattus norvegicus | 1 | ALA3621059 | organism-based format | Scientific Literature | |
18. | ALA3624668 | F | Reduction of albuminuria in angiotension-2 ZSF1 rat infusion model at 20 mg/kg administered through food admix treatment for 6 weeks | Rattus norvegicus | 1 | ALA3621059 | organism-based format | Scientific Literature | |
19. | ALA3624669 | F | Induction of improvement in glomerular filtration rate in angiotension-2 ZSF1 rat infusion model at 20 mg/kg administered through food admix treatment for 6 weeks | Rattus norvegicus | 1 | ALA3621059 | organism-based format | Scientific Literature | |
20. | ALA3624670 | F | Induction of improvement in renal histology in angiotension-2 ZSF1 rat infusion model at 20 mg/kg administered through food admix treatment for 6 weeks | Rattus norvegicus | 1 | ALA3621059 | organism-based format | Scientific Literature |