| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3626166 | B | Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as reduction in Wnt ligand-driven LEF/TCF-dependent transcriptional activity | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 2. | ALA3626167 | B | Inhibition of porcupine (unknown origin) expressed in HEK293T cells transfected with pLinbin- Wnt3A plasmid assessed as inhibition of Wnt3A secretion at 0.1 uM incubated for 48 hrs by Western blotting method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA3626168 | P | Chemical stability in simulated gastric fluid assessed as remaining compound level incubated for 0 hrs at 200 uM at 40 degC by HPLC method | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA3626169 | P | Chemical stability in simulated gastric fluid assessed as remaining compound level incubated for 4 hrs at 200 uM at 40 degC by HPLC method | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA3626170 | P | Chemical stability in simulated gastric fluid assessed as remaining compound level incubated for 8 hrs at 200 uM at 40 degC by HPLC method | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA3626171 | A | Stability of the compound in rat plasma assessed as drug remaining at 1 uM incubated for 30 mins by LC-MS/MS method | Rattus norvegicus | 5 | cell-free format | Scientific Literature | ||
| 7. | ALA3626172 | A | Stability of the compound in rat plasma assessed as drug remaining at 1 uM incubated for 1 hr by LC-MS/MS method | Rattus norvegicus | 5 | cell-free format | Scientific Literature | ||
| 8. | ALA3626173 | A | Stability of the compound in rat plasma assessed as drug remaining at 1 uM incubated for 8 hr by LC-MS/MS method | Rattus norvegicus | 5 | cell-free format | Scientific Literature | ||
| 9. | ALA3626174 | A | Intrinsic clearance in human liver microsomes at 1 uM incubated for 60 mins in presence of NADPH by LC-MS/MS method | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 10. | ALA3626175 | A | Intrinsic clearance in mouse liver microsomes at 1 uM incubated for 60 mins in presence of NADPH by LC-MS/MS method | Mus musculus | 5 | assay format | Scientific Literature | ||
| 11. | ALA3626176 | A | Half life in human liver microsomes at 1 uM in presence of NADPH by LC-MS/MS method | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 12. | ALA3626177 | A | Half life in mouse liver microsomes at 1 uM in presence of NADPH by LC-MS/MS method | Mus musculus | 5 | assay format | Scientific Literature | ||
| 13. | ALA3626178 | A | Inhibition of CYP3A4 in human liver microsomes at 10 uM pre-incubated for 10 mins before midazolam substrate and NADPH addition by LC-MS/MS method | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 14. | ALA3626179 | A | Inhibition of CYP2D6 in human liver microsomes at 10 uM pre-incubated for 10 mins before dextromethorphan substrate and NADPH addition by LC-MS/MS method | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 15. | ALA3626181 | A | Effect on total intracellular Wnt3a levels in HEK293T cells transfected with pLinbin- Wnt3A plasmid at 0.1 uM incubated for 48 hrs by Western blotting method | Homo sapiens | 4 | cell-based format | Scientific Literature |
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