| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3631169 | F | Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM dye based fluorescence analysis | Homo sapiens | 37 | ALA3627606 | cell-based format | Scientific Literature | |
| 2. | ALA3631170 | F | Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM dye based fluorescence analysis relative to glutamate | Homo sapiens | 18 | ALA3627606 | cell-based format | Scientific Literature | |
| 3. | ALA3631171 | F | Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay | Homo sapiens | 7 | ALA3627606 | cell-based format | Scientific Literature | |
| 4. | ALA3631328 | F | Positive allosteric modulation of human mGlu4 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay relative to glutamate | Homo sapiens | 7 | ALA3627606 | cell-based format | Scientific Literature | |
| 5. | ALA3631329 | B | Selectivity index, ratio of EC50 for human mGlu4 receptor to EC50 for human mGlu1 receptor | Homo sapiens | 7 | ALA3627606 | assay format | Scientific Literature | |
| 6. | ALA3631330 | F | Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay | Rattus norvegicus | 4 | ALA3627606 | cell-based format | Scientific Literature | |
| 7. | ALA3631331 | F | Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay relative to glutamate | Rattus norvegicus | 3 | ALA3627606 | cell-based format | Scientific Literature | |
| 8. | ALA3631332 | F | Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion at 10 uM by Fluo-4AM dye based fluorescence analysis | Homo sapiens | 3 | ALA3627606 | cell-based format | Scientific Literature | |
| 9. | ALA3631333 | F | Agonist activity at human mGlu1 receptor in HEK293 cells assessed as calcium mobilization at 10 uM by Fluo-4AM dye based fluorescence analysis | Homo sapiens | 3 | ALA3627606 | cell-based format | Scientific Literature | |
| 10. | ALA3631334 | B | Positive allosteric modulation of mGlu2 receptor (unknown origin) assessed as potentiation of glutamate-induced response by cell-based assay | Homo sapiens | 3 | ALA3627606 | cell-based format | Scientific Literature | |
| 11. | ALA3631335 | B | Positive allosteric modulation of mGlu3 receptor (unknown origin) assessed as potentiation of glutamate-induced response by cell-based assay | Homo sapiens | 3 | ALA3627606 | cell-based format | Scientific Literature | |
| 12. | ALA3631336 | B | Positive allosteric modulation of mGlu5 receptor (unknown origin) assessed as potentiation of glutamate-induced response by cell-based assay | Homo sapiens | 3 | ALA3627606 | cell-based format | Scientific Literature | |
| 13. | ALA3631337 | B | Positive allosteric modulation of mGlu6 receptor (unknown origin) assessed as potentiation of glutamate-induced response by cell-based assay | Homo sapiens | 3 | ALA3627606 | cell-based format | Scientific Literature | |
| 14. | ALA3631338 | B | Positive allosteric modulation of mGlu7 receptor (unknown origin) assessed as potentiation of glutamate-induced response by cell-based assay | Homo sapiens | 3 | ALA3627606 | cell-based format | Scientific Literature | |
| 15. | ALA3631339 | B | Positive allosteric modulation of mGlu8 receptor (unknown origin) assessed as potentiation of glutamate-induced response by cell-based assay | Homo sapiens | 3 | ALA3627606 | cell-based format | Scientific Literature | |
| 16. | ALA3631340 | A | Intrinsic clearance in human liver microsomes at 1 uM by LC-MS/MS analysis | Homo sapiens | 5 | ALA3627606 | assay format | Scientific Literature | |
| 17. | ALA3631341 | A | Intrinsic clearance in rat liver microsomes at 1 uM by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA3627606 | assay format | Scientific Literature | |
| 18. | ALA3631343 | A | Fraction unbound in rat plasma | Rattus norvegicus | 3 | ALA3627606 | cell-free format | Scientific Literature | |
| 19. | ALA3631344 | A | Metabolic stability in human plasma | Homo sapiens | 3 | ALA3627606 | cell-free format | Scientific Literature | |
| 20. | ALA3631346 | A | Inhibition of CYP1A2 in human liver microsomes by LC-MS/MS analysis | Homo sapiens | 5 | ALA3627606 | assay format | Scientific Literature |
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