# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3631636 | B | Displacement of [3H]-Epibatidine from alpha4beta2* nAChR in Sprague-Dawley rat cortical membranes pre-incubated for 5 mins followed by overnight incubation by radioligand liquid scintillation counter analysis | Rattus norvegicus | 12 | ALA3627604 | assay format | Scientific Literature | |
2. | ALA3631637 | B | Displacement of [125I]alpha-Bungarotoxin from alpha7 nAChR in Sprague-Dawley rat hippocampal membranes pre-incubated for 5 mins followed by overnight incubation by radioligand liquid scintillation counter analysis | Rattus norvegicus | 12 | ALA3627604 | assay format | Scientific Literature | |
3. | ALA3631638 | B | Selectivity ratio of Ki for alpha7 nAChR in Sprague-Dawley rat hippocampal membranes to Ki for alpha4beta2 nAChR in Sprague-Dawley rat cortical membranes | Rattus norvegicus | 12 | ALA3627604 | assay format | Scientific Literature | |
4. | ALA3631640 | B | Displacement of [3H]-Epibatidine from aplha6beta2* nAChR in Sprague-Dawley rat cortical membranes pre-incubated for 5 mins followed by overnight incubation by radioligand liquid scintillation counter analysis | Rattus norvegicus | 4 | ALA3627604 | assay format | Scientific Literature | |
5. | ALA3631641 | B | Displacement of [3H]-Epibatidine from human aplha3beta4 nAChR expressed in HEK293 cells pre-incubated for 5 mins followed by overnight incubation by radioligand liquid scintillation counter analysis | Homo sapiens | 4 | ALA3627604 | cell-based format | Scientific Literature | |
6. | ALA3631642 | B | Agonist activity at alpha4beta2 nAChR in Sprague-Dawley rat striatal slices assessed as increase in [3H]-Dopamine release after 5 mins by microbeta counting | Rattus norvegicus | 5 | ALA3627604 | protein complex format | Scientific Literature | |
7. | ALA3631644 | B | Antagonist activity against alpha6beta2* nAChR in Sprague-Dawley rat cortical slices assessed as inhibition of nicotine-induced [3H]-dopamine release after 5 mins by microbeta counting | Rattus norvegicus | 2 | ALA3627604 | assay format | Scientific Literature | |
8. | ALA3631755 | B | Selectivity ratio of Ki for aplha6beta2* nAChR in Sprague-Dawley rat cortical membranes to Ki for human aplha3beta4 nAChR expressed in HEK293 cells | 2 | ALA3627604 | cell-based format | Scientific Literature |