# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3631861 | B | Inhibition of 5-LO in mouse BMM cells assessed as formation of LTC4 after 30 mins by enzyme immunoassay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
2. | ALA3631862 | F | Antiosteoclast activity in mouse BMM cells assessed as reduction of RANKL-induced osteoclasts differentiation by measuring TRAP positive multinucleated cells after 4 days by light microscopy | Mus musculus | 4 | cell-based format | Scientific Literature | ||
3. | ALA3631863 | A | Cytotoxicity against mouse BMM cells assessed as cell survival after 4 days by MTT assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
4. | ALA3631864 | F | Antiosteoclast activity in mouse BMM cells assessed as reduction of M-CSF and RANKL-induced formation of bone resorption pits at 10 uM after 2 days by toluidine blue staining based bone resorption assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
5. | ALA3631865 | F | Antiosteoclast activity in mouse BMM cells assessed as reduction of RANKL-induced ATP6V0D2 mRNA expression at 10 uM after 4 days by RT-PCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
6. | ALA3631866 | F | Antiosteoclast activity in mouse BMM cells assessed as reduction of RANKL-induced alpha v-integrin mRNA expression at 10 uM after 4 days by RT-PCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
7. | ALA3631867 | F | Antiosteoclast activity in mouse BMM cells assessed as reduction of RANKL-induced cathepsin K mRNA expression at 10 uM after 4 days by RT-PCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
8. | ALA3631868 | F | Antiosteoclast activity in mouse BMM cells assessed as reduction of RANKL-induced DC-STAMP mRNA expression at 10 uM after 4 days by RT-PCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
9. | ALA3632397 | F | Antiosteoclast activity in mouse BMM cells assessed as reduction of RANKL-induced beta3-integrin mRNA expression at 10 uM after 4 days by RT-PCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
10. | ALA3632398 | B | Inhibition of MAPK/NF-kappaB in mouse BMM cells assessed as down regulation of RANKL-induced NFATc1 expression at 10 uM pre-treated for 30 mins before RANKL-stimulation for 24 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
11. | ALA3632399 | F | Antiosteoclast activity in mouse BMM cells over-expressing constitutively active NFATc1 assessed as suppression of RANKL-induced osteoclast formation at 10 uM after 4 days by TRAP+ staining based method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
12. | ALA3632400 | B | Inhibition of ERK phosphorylation in mouse BMM cells at 10 uM pre-incubated for 30 mins before RANKL-stimulation for 15 mins by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
13. | ALA3632401 | B | Inhibition of p38 phosphorylation in mouse BMM cells at 10 uM pre-incubated for 30 mins before RANKL-stimulation for 15 mins by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
14. | ALA3632402 | B | Inhibition of NFkappaB in mouse BMM cells assessed as suppression of RANKL-induced IkappaB degradation at 10 uM pre-incubated for 30 mins before RANKL-stimulation for 15 mins by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
15. | ALA3632403 | F | Antiosteoclast activity in mouse BMM cells assessed as reduction of LPS-induced osteoclast formation at 10 uM after 4 days by TRAP+ staining based light microscopy | Mus musculus | 1 | cell-based format | Scientific Literature | ||
16. | ALA3632404 | F | Antiosteoclast activity in mouse assessed as reduction of LPS-induced osteoclast formation in calvarial bone at 5 mg/kg, ip administered daily with LPS challenge after first day of compound dosing measured 6 days after LPS injection | Mus musculus | 1 | organism-based format | Scientific Literature |