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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA3636369 B Inhibition of TPO (unknown origin) using Amplex Red as substrate assessed as formation of resorufin by measuring ratio of Kinact to Ki measured every 20 secs by spectrophotometric analysis Homo sapiens 9 single protein format Scientific Literature 2. ALA3636508 P Lipophilicity, log D of the compound at pH 7.4 by shake-flask method 9 small-molecule physicochemical format Scientific Literature 3. ALA3636510 B Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin by measuring ratio of Kinact to Ki measured every 20 secs by spectrophotometric analysis Homo sapiens 9 assay format Scientific Literature 4. ALA3636511 B Irreversible inhibition of MPO in LPS-stimulated human whole blood after 4 hrs by Amplex Red/H2O2-based fluorescence plate reader analysis Homo sapiens 9 single protein format Scientific Literature 5. ALA3636521 A Apparent permeability across RRCK cells Canis lupus familiaris 7 cell-based format Scientific Literature 6. ALA3636524 P Drug metabolism in sodium phosphate buffer assessed as formation of GSH adduct at 10 uM after 60 mins by LC-MS/MS analysis in presence of human MPO/H2O2/Cl-/excess GSH 4 small-molecule physicochemical format Scientific Literature 7. ALA3636525 A Fraction unbound in human plasma by equilibrium dialysis method Homo sapiens 6 cell-free format Scientific Literature 8. ALA3636526 A Intrinsic apparent clearance in human liver microsomes Homo sapiens 7 assay format Scientific Literature 9. ALA3636527 A Intrinsic apparent clearance in human hepatocytes assessed per 10'6 cells Homo sapiens 7 cell-based format Scientific Literature 10. ALA3636528 A Plasma clearance in Wistar rat at 1 mg/kg, iv and 3 or 5 mg/kg, po Rattus norvegicus 6 organism-based format Scientific Literature 11. ALA3636529 A Plasma clearance in Beagle dog at 1 mg/kg, iv and 3 or 5 mg/kg, po Canis lupus familiaris 6 organism-based format Scientific Literature 12. ALA3636532 A Volume of distribution at steady state in Wistar rat at 1 mg/kg, iv and 3 or 5 mg/kg, po Rattus norvegicus 6 organism-based format Scientific Literature 13. ALA3636533 A Volume of distribution at steady state in Beagle dog at 1 mg/kg, iv and 3 or 5 mg/kg, po Canis lupus familiaris 6 organism-based format Scientific Literature 14. ALA3636536 A Elimination half life in Wistar rat at 1 mg/kg, iv and 3 or 5 mg/kg, po Rattus norvegicus 6 organism-based format Scientific Literature 15. ALA3636537 A Elimination half life in Beagle dog at 1 mg/kg, iv and 3 or 5 mg/kg, po Canis lupus familiaris 6 organism-based format Scientific Literature 16. ALA3636540 A Tmax in Wistar rat at 3 or 5 mg/kg, po Rattus norvegicus 6 organism-based format Scientific Literature 17. ALA3636541 A Tmax in Beagle dog at 3 or 5 mg/kg, po Canis lupus familiaris 6 organism-based format Scientific Literature 18. ALA3636544 A Oral bioavailability in Wistar rat at 3 or 5 mg/kg Rattus norvegicus 6 organism-based format Scientific Literature 19. ALA3636545 A Oral bioavailability in Beagle dog at 3 or 5 mg/kg Canis lupus familiaris 6 organism-based format Scientific Literature