# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3636035 | B | Potency index, ratio of compound activity to CPT activity for inhibition of recombinant human topoisomerase 1 at 100 uM | Homo sapiens | 28 | ALA3632492 | single protein format | Scientific Literature | |
2. | ALA3636036 | B | Inhibition of recombinant human topoisomerase 1 assessed as relaxation of supercoiled plasmid DNA pBR322 at 100 uM incubated for 30 mins by agarose gel electrophoresis | Homo sapiens | 30 | ALA3632492 | single protein format | Scientific Literature | |
3. | ALA3636037 | B | Inhibition of recombinant human topoisomerase 1 assessed as relaxation of supercoiled plasmid DNA pBR322 at 20 uM incubated for 30 mins by agarose gel electrophoresis | Homo sapiens | 30 | ALA3632492 | single protein format | Scientific Literature | |
4. | ALA3636038 | B | Inhibition of recombinant human topoisomerase 2alpha assessed as relaxation of supercoiled plasmid DNA pBR322 at 100 uM incubated for 30 mins by agarose gel electrophoresis | Homo sapiens | 30 | ALA3632492 | single protein format | Scientific Literature | |
5. | ALA3636039 | B | Inhibition of recombinant human topoisomerase 2alpha assessed as relaxation of supercoiled plasmid DNA pBR322 at 20 uM incubated for 30 mins by agarose gel electrophoresis | Homo sapiens | 30 | ALA3632492 | single protein format | Scientific Literature | |
6. | ALA3636040 | B | Potency index, ratio of compound activity to CPT activity for inhibition of recombinant human topoisomerase 1 at 20 uM | Homo sapiens | 19 | ALA3632492 | single protein format | Scientific Literature | |
7. | ALA3636045 | F | Cytotoxicity against human HCT15 cells measured after 2 days by MTT assay | Homo sapiens | 32 | ALA3632492 | cell-based format | Scientific Literature | |
8. | ALA3636046 | F | Cytotoxicity against human T47D cells measured after 2 days by MTT assay | Homo sapiens | 32 | ALA3632492 | cell-based format | Scientific Literature | |
9. | ALA3636047 | F | Cytotoxicity against human HeLa cells measured after 2 days by MTT assay | Homo sapiens | 32 | ALA3632492 | cell-based format | Scientific Literature |