| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3636834 | Functional | Antileishmanial activity against promastigote stage of Leishmania major Friedlin clone V1 assessed as parasite survival after 72 hrs by luciferase reporter gene assay | Leishmania major | 27 | ALA3632600 | organism-based format | Scientific Literature | |
| 2. | ALA3636836 | ADME | Cytotoxicity against monkey LLC-MK2 cells after 96 hrs by Alamar Blue assay | Macaca mulatta | 1 | ALA3632600 | cell-based format | Scientific Literature | |
| 3. | ALA3784402 | Functional | Antiferroptotic activity in human IMR32 neuroblastoma cells assessed as inhibition of erastin-induced cell death preincubated for 1 hr before erastin stimulation and measured after 13 hrs by fluorescence plate reader method | Homo sapiens | 39 | ALA3779804 | assay format | Scientific Literature | |
| 4. | ALA3784403 | Physicochemical | Kinetic solubility of the compound in PBS buffer at pH 7.4 after 2 hrs at 37 deg C by turbidimetric analysis | 6 | ALA3779804 | small-molecule physicochemical format | Scientific Literature | ||
| 5. | ALA3784404 | ADME | Half life in human liver microsomes by LC/MS/MS analysis | Homo sapiens | 6 | ALA3779804 | tissue-based format | Scientific Literature | |
| 6. | ALA3784405 | ADME | Half life in mouse liver microsomes by LC/MS/MS analysis | Mus musculus | 6 | ALA3779804 | tissue-based format | Scientific Literature | |
| 7. | ALA3784406 | ADME | Stability in human plasma assessed as percentage recovery after 6 hrs by LC/MS/MS analysis | Homo sapiens | 6 | ALA3779804 | cell-free format | Scientific Literature | |
| 8. | ALA3784407 | ADME | Stability in mouse plasma assessed as percentage recovery after 6 hrs by LC/MS/MS analysis | Mus musculus | 6 | ALA3779804 | cell-free format | Scientific Literature | |
| 9. | ALA3784408 | Functional | Antiferroptotic activity in human HT1080 cells assessed as inhibition of erastin-induced cell death by Alamar blue assay | Homo sapiens | 2 | ALA3779804 | cell-based format | Scientific Literature | |
| 10. | ALA4158878 | Functional | Inhibition of erastin-induced ferroptosis in human IMR32 cells preincubated for 1 hr followed by erastin stimulation and measured after 13 hrs by sytox green-based fluorescence assay | Homo sapiens | 22 | ALA4152389 | cell-based format | Scientific Literature | |
| 11. | ALA4158879 | Physicochemical | Kinetic solubility in PBS at pH 7.4 after 2 hrs by turbidimetric method | 22 | ALA4152389 | small-molecule physicochemical format | Scientific Literature | ||
| 12. | ALA4158880 | ADME | Half life in human liver microsomes at 10 uM in presence of NADPH regenerating system by LC/MS/MS analysis | Homo sapiens | 5 | ALA4152389 | microsome format | Scientific Literature | |
| 13. | ALA4158881 | ADME | Half life in rat liver microsomes at 10 uM in presence of NADPH regenerating system by LC/MS/MS analysis | Rattus norvegicus | 5 | ALA4152389 | microsome format | Scientific Literature | |
| 14. | ALA4158882 | ADME | Half life in mouse liver microsomes at 10 uM in presence of NADPH regenerating system by LC/MS/MS analysis | Mus musculus | 5 | ALA4152389 | microsome format | Scientific Literature | |
| 15. | ALA4158883 | ADME | Metabolic stability in human plasma assessed as compound recovery at 50 uM after 6 hrs by LC/MS/MS analysis | Homo sapiens | 5 | ALA4152389 | cell-free format | Scientific Literature | |
| 16. | ALA4158884 | ADME | Metabolic stability in rat plasma assessed as compound recovery at 50 uM after 6 hrs by LC/MS/MS analysis | Rattus norvegicus | 5 | ALA4152389 | cell-free format | Scientific Literature | |
| 17. | ALA4158885 | ADME | Metabolic stability in mouse plasma assessed as compound recovery at 50 uM after 6 hrs by LC/MS/MS analysis | Mus musculus | 5 | ALA4152389 | cell-free format | Scientific Literature | |
| 18. | ALA4158889 | Functional | Inhibition of ferrous ammonium sulphate-induced ferroptosis in human IMR32 cells preincubated for 1 hr followed by erastin stimulation and measured after 13 hrs by sytox green-based fluorescence assay | Homo sapiens | 4 | ALA4152389 | cell-based format | Scientific Literature | |
| 19. | ALA4158890 | Functional | In vivo inhibition of iron sulphate-induced ferroptosis in C57BL/6N mouse assessed as LDH levels in plasma at 20 umol/kg, iv administered 15 mins prior to acute iron poisoning and measured after 2 hrs (Rvb = 3572 +/- 185 U/L) | Mus musculus | 4 | ALA4152389 | organism-based format | Scientific Literature | |
| 20. | ALA4303805 | Functional | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging | Homo sapiens | 5,612 | ALA4303101 | organism-based format | SARS-CoV-2 Screening Data 2020-21 |
The page will load shortly, Thanks for your patience!