| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3635176 | P | Dissociation constant, pKa of the compound by potentiometric titration assay | 18 | small-molecule physicochemical format | Scientific Literature | |||
| 2. | ALA3635177 | B | Inhibition of BACE1 (unknown origin) using APP Swedish mutant harboring Lys-Met/Asn-Leu mutation in beta-secretase cleavage site as substrate by FRET assay | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 3. | ALA3635178 | B | Inhibition of BACE1 in human SKNBE2 cells expressing wild type human APP695 assessed as reduction in amyloid beta-42 production after 18 hrs by sandwich alphalisa assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 4. | ALA3635179 | B | Inhibition of BACE1 in mouse Neuro-2a cells expressing wild type human APP695 assessed as reduction in amyloid beta-42 production after 18 hrs by sandwich alphalisa assay | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA3635180 | A | Drug metabolism in human liver microsomes at 1 uM after 15 min by HPLC-MS/MS analysis | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 6. | ALA3635181 | A | Drug metabolism in mouse liver microsomes at 1 uM after 15 min by HPLC-MS/MS analysis | Mus musculus | 7 | assay format | Scientific Literature | ||
| 7. | ALA3635182 | A | Fraction unbound in rat brain at 5 uM after 5 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 7 | tissue-based format | Scientific Literature | ||
| 8. | ALA3635183 | A | Fraction unbound in human plasma at 5 uM after 4.5 hrs by HPLC-MS/MS analysis | Homo sapiens | 7 | cell-free format | Scientific Literature | ||
| 9. | ALA3635351 | A | Fraction unbound in mouse plasma at 5 uM after 4.5 hrs by HPLC-MS/MS analysis | Mus musculus | 7 | cell-free format | Scientific Literature | ||
| 10. | ALA3635352 | A | Apparent permeability across apical to basolateral side in pig LLC cells transfected with human MDR1 at 5 uM by HPLC-MS/MS analysis | Sus scrofa | 12 | cell-based format | Scientific Literature | ||
| 11. | ALA3635353 | A | Apparent permeability across apical to basolateral side in pig LLC cells transfected with human MDR1 at 5 uM by HPLC-MS/MS analysis in the presence of P-gp inhibitor elacridar | Sus scrofa | 12 | cell-based format | Scientific Literature | ||
| 12. | ALA3635354 | A | Efflux ratio of apparent permeability across apical to basolateral side in pig LLC cells in presence of P-gp inhibitor elacridar over apical to basolateral side in pig LLC cells in absence of P-gp inhibitor elacridar | Sus scrofa | 12 | cell-based format | Scientific Literature | ||
| 13. | ALA3635361 | P | Distribution coefficient, logD of the compound by chromatography | 7 | small-molecule physicochemical format | Scientific Literature |
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