# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3637733 | F | Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay | Homo sapiens | 10 | ALA3632592 | cell-based format | Scientific Literature | |
2. | ALA3637734 | F | Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay | Homo sapiens | 10 | ALA3632592 | cell-based format | Scientific Literature | |
3. | ALA3635184 | P | Antioxidant activity assessed as inhibition of Fe2+-induced DMPO-OH adduct formation from H2O2 preincubated for 30 secs followed by DMPO/H2O2 addition measured after 150 secs by ESR analysis | 9 | ALA3632592 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA3635185 | U | Potency index, ratio of EDTA IC50 to compound IC50 for inhibition of Fe2+-induced DMPO-OH adduct formation from H2O2 | 7 | ALA3632592 | assay format | Scientific Literature | ||
5. | ALA3635186 | P | Antioxidant activity assessed as ABTS radical scavenging activity after 7 mins | 10 | ALA3632592 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA3635187 | P | Metal chelating activity assessed as inhibition of Fe2+-ferrozine complex formation at 80 uM after 10 mins relative to control | 1 | ALA3632592 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA3635190 | F | Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced reactive oxygen species formation after 1 hr by DCFH-DA dye-based fluorometric analysis | Rattus norvegicus | 10 | ALA3632592 | cell-based format | Scientific Literature | |
8. | ALA3635191 | F | Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced reactive oxygen species formation at 0.01 to 25 uM after 1 hr by DCFH-DA dye-based fluorometric analysis in presence of P2Y12R antagonist 2-MeS-AMP | Rattus norvegicus | 1 | ALA3632592 | cell-based format | Scientific Literature | |
9. | ALA3635192 | F | Antioxidant activity in human NTERA2 cells assessed as inhibition of Fe2+-induced reactive oxygen species formation at 0.2 uM after 1 hr by DCFH-DA dye-based fluorometric analysis relative to control | Homo sapiens | 1 | ALA3632592 | cell-based format | Scientific Literature | |
10. | ALA3635193 | F | Antioxidant activity in human NTERA2 cells assessed as inhibition of Fe2+-induced reactive oxygen species formation at 0.01 to 25 uM after 1 hr by DCFH-DA dye-based fluorometric analysis in presence of P2Y1R antagonist MRS2179 | Homo sapiens | 1 | ALA3632592 | cell-based format | Scientific Literature | |
11. | ALA3635194 | A | Drug metabolism assessed as human eNPP1-mediated compound hydrolysis at 4 mM after 2 hrs by reverse-phase HPLC analysis relative to ATP | Homo sapiens | 1 | ALA3632592 | single protein format | Scientific Literature | |
12. | ALA3635195 | A | Drug metabolism assessed as human eNPP3-mediated compound hydrolysis at 4 mM after 3 hrs by reverse-phase HPLC analysis relative to ATP | Homo sapiens | 1 | ALA3632592 | single protein format | Scientific Literature | |
13. | ALA3635198 | A | Half life in human serum at 37 degC by HPLC analysis | Homo sapiens | 3 | ALA3632592 | cell-free format | Scientific Literature | |
14. | ALA3635199 | A | Half life of the compound in RPMI-1640 medium at 37 degC by HPLC analysis | 3 | ALA3632592 | assay format | Scientific Literature | ||
15. | ALA3635204 | F | Neuroprotective activity against Fe2+-induced oxidative damage in rat primary cortical neurons assessed as cell viability after 24 hrs by MTT assay | Rattus norvegicus | 2 | ALA3632592 | cell-based format | Scientific Literature | |
16. | ALA3635205 | F | Neuroprotective activity against Fe2+-induced oxidative damage in rat primary cortical neurons assessed as cell viability at 0.01 to 25 uM after 24 hrs by MTT assay | Rattus norvegicus | 1 | ALA3632592 | cell-based format | Scientific Literature | |
17. | ALA3635206 | F | Neuroprotective activity against Fe2+-induced morphological changes in rat primary cortical neurons at 0.2 to 100 uM after 24 hrs by light microscopic analysis | Rattus norvegicus | 1 | ALA3632592 | cell-based format | Scientific Literature |