# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3636077 | Binding | Inhibition of recombinant Brugia malayi TMK using dTMP as substrate by pyruvate kinase/lactate dehydrogenase coupled assay | Brugia malayi | 15 | ALA3632586 | assay format | Scientific Literature | |
2. | ALA3636078 | Functional | Antifilarial activity against adult Brugia malayi assessed as motility reduction after 1 hr by microscopic analysis | Brugia malayi | 3 | ALA3632586 | organism-based format | Scientific Literature | |
3. | ALA3636079 | Functional | Antifilarial activity against Brugia malayi microfilariae assessed as motility reduction after 1 hr by microscopic analysis | Brugia malayi | 3 | ALA3632586 | organism-based format | Scientific Literature | |
4. | ALA3636080 | ADME | Cytotoxicity against African green monkey Vero cells after 72 hrs by resazurin dye-based fluorometric analysis | Chlorocebus sabaeus | 3 | ALA3632586 | cell-based format | Scientific Literature | |
5. | ALA3636081 | ADME | Therapeutic index, ratio of CC50 for monkey VERO cells to IC50 for adult Brugia malayi | 3 | ALA3632586 | cell-based format | Scientific Literature | ||
6. | ALA3636082 | ADME | Therapeutic index, ratio of CC50 for monkey VERO cells to IC50 for Brugia malayi microfilariae | 3 | ALA3632586 | cell-based format | Scientific Literature | ||
7. | ALA3636083 | Functional | Antifilarial activity against adult Brugia malayi assessed as reduction in viability at 10 uM/ml after 24 to 48 hrs by MTT assay | Brugia malayi | 2 | ALA3632586 | organism-based format | Scientific Literature | |
8. | ALA3636084 | Functional | Antifilarial activity against adult Brugia malayi assessed as reduction in viability at 5 uM/ml after 24 to 48 hrs by MTT assay | Brugia malayi | 3 | ALA3632586 | organism-based format | Scientific Literature | |
9. | ALA3636085 | Functional | Antifilarial activity against adult Brugia malayi assessed as reduction in viability at 2.5 uM/ml after 24 to 48 hrs by MTT assay | Brugia malayi | 3 | ALA3632586 | organism-based format | Scientific Literature | |
10. | ALA3636086 | Functional | Antifilarial activity against adult Brugia malayi assessed as reduction in viability at 1.25 uM/ml after 24 to 48 hrs by MTT assay | Brugia malayi | 3 | ALA3632586 | organism-based format | Scientific Literature | |
11. | ALA3636091 | Functional | Antifilarial activity against adult Brugia malayi assessed as motility reduction at 10 uM/ml after 1 hr by microscopic analysis | Brugia malayi | 2 | ALA3632586 | organism-based format | Scientific Literature | |
12. | ALA3636092 | Functional | Antifilarial activity against adult Brugia malayi assessed as motility reduction at 5 uM/ml after 1 hr by microscopic analysis | Brugia malayi | 3 | ALA3632586 | organism-based format | Scientific Literature | |
13. | ALA3636093 | Functional | Antifilarial activity against adult Brugia malayi assessed as motility reduction at 2.5 uM/ml after 1 hr by microscopic analysis | Brugia malayi | 3 | ALA3632586 | organism-based format | Scientific Literature | |
14. | ALA3636094 | Functional | Antifilarial activity against adult Brugia malayi assessed as motility reduction at 1.25 uM/ml after 1 hr by microscopic analysis | Brugia malayi | 3 | ALA3632586 | organism-based format | Scientific Literature | |
15. | ALA3636203 | Functional | Antifilarial activity against Brugia malayi microfilariae assessed as motility reduction at 10 uM/ml after 1 hr by microscopic analysis | Brugia malayi | 2 | ALA3632586 | organism-based format | Scientific Literature | |
16. | ALA3636204 | Functional | Antifilarial activity against Brugia malayi microfilariae assessed as motility reduction at 5 uM/ml after 1 hr by microscopic analysis | Brugia malayi | 3 | ALA3632586 | organism-based format | Scientific Literature | |
17. | ALA3636205 | Functional | Antifilarial activity against Brugia malayi microfilariae assessed as motility reduction at 2.5 uM/ml after 1 hr by microscopic analysis | Brugia malayi | 3 | ALA3632586 | organism-based format | Scientific Literature | |
18. | ALA3636702 | Functional | Antifilarial activity against Brugia malayi microfilariae assessed as motility reduction at 1.25 uM/ml after 1 hr by microscopic analysis | Brugia malayi | 3 | ALA3632586 | organism-based format | Scientific Literature |